Programming off and on states in chromatin: Mechanisms of Polycomb and trithorax group complexes

Jeffrey A. Simon, John W. Tamkun

Research output: Contribution to journalReview articlepeer-review

294 Scopus citations


Polycomb and trithorax group proteins are evolutionarily conserved chromatin components that maintain stable states of gene expression. Recent studies have identified and characterized several multiprotein complexes containing these transcriptional regulators. Advances in understanding molecular activities of these complexes in vitro, and functional domains present in their subunits, suggest that they control transcription through multistep mechanisms that involve nucleosome modification, chromatin remodeling, and interaction with general transcription factors.

Original languageEnglish (US)
Pages (from-to)210-218
Number of pages9
JournalCurrent Opinion in Genetics and Development
Issue number2
StatePublished - Apr 1 2002

Bibliographical note

Funding Information:
We thank Ann Rougvie, Mike O'Connor and members of our laboratories for discussions and critical comments on the manuscript. We apologize to colleagues whose work we were unable to cite due to space limitations. Work in our laboratories is supported by grants from the National Institutes of Health.


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