Programming for CD8 T cell memory development requires IL-120 or type I IFN

Zhengguo Xiao, Kerry A. Casey, Stephen C. Jameson, Julie M. Curtsinger, Matthew F. Mescher

Research output: Contribution to journalArticlepeer-review

172 Scopus citations


Inflammation can have both positive and negative effects on development of CD8 T cell memory, but the relative contributions and cellular targets of the cytokines involved are unclear. Using CD8 T cells lacking receptors for IL-12, type I IFN, or both, we show that these cytokines act directly on CD8 T cells to support memory formation in response to vaccinia virus and Listeria monocytogenes infections. Development of memory to vaccinia is supported predominantly by IL-12, whereas both IL-12 and type I IFN contribute to memory formation in response to Listeria. In contrast to memory formation, the inability to respond to IL-12 or type I IFN had a relatively small impact on the level of primary expansion, with at most a 3-fold reduction in the case of responses to Listeria. We further show that programming for memory development by IL-12 is complete within 3 days of the initial naive CD8 T cell response to Ag. This programming does not result in formation of a population that expresses killer cell lectin-like receptor G1, and the majority of the resulting memory cells have a CD62Lhigh phenotype characteristic of central memory cells. Consistent with this, the cells undergo strong expansion upon rechallenge and provide protective immunity. These data demonstrate that IL-12 and type I IFN play an essential early role in determining whether Ag encounter by naive CD8 T cells results in formation of a protective memory population.

Original languageEnglish (US)
Pages (from-to)2786-2794
Number of pages9
JournalJournal of Immunology
Issue number5
StatePublished - Mar 1 2009


Dive into the research topics of 'Programming for CD8 T cell memory development requires IL-120 or type I IFN'. Together they form a unique fingerprint.

Cite this