Programmable self-assembly of antibody-oligonucleotide conjugates as small molecule and protein carriers

Amit Gangar, Adrian Fegan, Sidath C Kumarapperuma, Carston R Wagner

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Dihydrofolate reductase single-chain variable fragment (scFv) fusion proteins can be used for the targeted cellular delivery of oligonucleotides, conjugated small molecules, and proteins via labeling of oligonucleotides by bis-methotrexate.

Original languageEnglish (US)
Pages (from-to)2895-2897
Number of pages3
JournalJournal of the American Chemical Society
Volume134
Issue number6
DOIs
StatePublished - Feb 15 2012

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Oligonucleotides
Antibodies
Self assembly
Carrier Proteins
Proteins
Single-Chain Antibodies
Tetrahydrofolate Dehydrogenase
Molecules
Methotrexate
Labeling
Fusion reactions
Oxidoreductases

Cite this

Programmable self-assembly of antibody-oligonucleotide conjugates as small molecule and protein carriers. / Gangar, Amit; Fegan, Adrian; Kumarapperuma, Sidath C; Wagner, Carston R.

In: Journal of the American Chemical Society, Vol. 134, No. 6, 15.02.2012, p. 2895-2897.

Research output: Contribution to journalArticle

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