Program on the surgical control of the hyperlipidemias (POSCH): Patient entry characteristics

John P. Matts; Henry Buchwald; Laurie L. Fitch; Christian T. Campos; Richard L. Varco; Gilbert S. Campbell; Malcolm B. Pearce; Albert E. Yellin; W. Allan Edmiston; Robert D. Smink; Henry S. Sawin; Betty J. Hansen; John M. Long

doi:10.1016/0197-2456(91)90028-K

Program on the surgical control of the hyperlipidemias (POSCH): Patient entry characteristics

John P. Matts, Henry Buchwald, Laurie L. Fitch, Christian T. Campos, Richard L. Varco, Gilbert S. Campbell, Malcolm B. Pearce, Albert E. Yellin, W. Allan Edmiston, Robert D. Smink, Henry S. Sawin, Betty J. Hansen, John M. Long

Surgery

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Abstract

The entry characteristics of patients in the Program on the Surgical Control of the Hyperlipidemias (POSCH), a randomized, controlled, clinical trial, are described in this article. The primary objective addressed by POSCH was whether lowering total plasma cholesterol by partial ileal bypass surgery results in a reduction in mortality and morbidity in post-myocardial infarction patients. Between 1975 and 1983, 838 patients between the ages of 30 and 64 years were randomized into POSCH. The mean age at entry was 51 years, and 91% of the patients were men. The mean time between myocardial infarction and entry was 2.2 years. The mean baseline total plasma cholesterol was 251 mg/dl, with a mean LDL-cholesterol of 179 mg/dl and a mean HDL-cholesterol of 40 mg/dl. Significant disease (≥50% occlusion) of one or more major coronary arteries was found in 91% of the patients. In addition to a description of the POSCH patient population at entry, comparisons of the POSCH patient population to populations of participants in other lipid-lowering trials are presented to provide a perspective on how POSCH relates to these trials.

Original language	English (US)
Pages (from-to)	314-339
Number of pages	26
Journal	Controlled clinical trials
Volume	12
Issue number	2
DOIs	https://doi.org/10.1016/0197-2456(91)90028-K
State	Published - Apr 1991

Bibliographical note

Funding Information:
This work was supported by Grant HL15265 from the National Heart, Lung, and Blood Institute.

Keywords

POSCH
Randomized clinical trial
atherosclerosis
cholestesol
coronary heart disease
hyperlipidemia
partial ileal bypass

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0197-2456(91)90028-K

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Matts, J. P., Buchwald, H., Fitch, L. L., Campos, C. T., Varco, R. L., Campbell, G. S., Pearce, M. B., Yellin, A. E., Edmiston, W. A., Smink, R. D., Sawin, H. S., Hansen, B. J., & Long, J. M. (1991). Program on the surgical control of the hyperlipidemias (POSCH): Patient entry characteristics. Controlled clinical trials, 12(2), 314-339. https://doi.org/10.1016/0197-2456(91)90028-K

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title = "Program on the surgical control of the hyperlipidemias (POSCH): Patient entry characteristics",

abstract = "The entry characteristics of patients in the Program on the Surgical Control of the Hyperlipidemias (POSCH), a randomized, controlled, clinical trial, are described in this article. The primary objective addressed by POSCH was whether lowering total plasma cholesterol by partial ileal bypass surgery results in a reduction in mortality and morbidity in post-myocardial infarction patients. Between 1975 and 1983, 838 patients between the ages of 30 and 64 years were randomized into POSCH. The mean age at entry was 51 years, and 91% of the patients were men. The mean time between myocardial infarction and entry was 2.2 years. The mean baseline total plasma cholesterol was 251 mg/dl, with a mean LDL-cholesterol of 179 mg/dl and a mean HDL-cholesterol of 40 mg/dl. Significant disease (≥50% occlusion) of one or more major coronary arteries was found in 91% of the patients. In addition to a description of the POSCH patient population at entry, comparisons of the POSCH patient population to populations of participants in other lipid-lowering trials are presented to provide a perspective on how POSCH relates to these trials.",

keywords = "POSCH, Randomized clinical trial, atherosclerosis, cholestesol, coronary heart disease, hyperlipidemia, partial ileal bypass",

author = "Matts, {John P.} and Henry Buchwald and Fitch, {Laurie L.} and Campos, {Christian T.} and Varco, {Richard L.} and Campbell, {Gilbert S.} and Pearce, {Malcolm B.} and Yellin, {Albert E.} and Edmiston, {W. Allan} and Smink, {Robert D.} and Sawin, {Henry S.} and Hansen, {Betty J.} and Long, {John M.}",

note = "Funding Information: This work was supported by Grant HL15265 from the National Heart, Lung, and Blood Institute.",

year = "1991",

month = apr,

doi = "10.1016/0197-2456(91)90028-K",

language = "English (US)",

volume = "12",

pages = "314--339",

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AU - Campos, Christian T.

AU - Varco, Richard L.

AU - Campbell, Gilbert S.

AU - Pearce, Malcolm B.

AU - Yellin, Albert E.

AU - Edmiston, W. Allan

AU - Smink, Robert D.

AU - Sawin, Henry S.

AU - Hansen, Betty J.

AU - Long, John M.

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KW - coronary heart disease

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Program on the surgical control of the hyperlipidemias (POSCH): Patient entry characteristics

Abstract

Bibliographical note

Keywords

UN SDGs

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