Prognostic value of genome-wide DNA methylation patterns in noncoding miRNAs and lncRNAs in uveal melanomas

Zheng Zheng, Dan Xu, Keqing Shi, Minfeng Chen, Fan Lu

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: Uveal melanomas are the most common primary intraocular malignant tumors in adults, associated with a high metastasis rate and a low 5-year survival rate. It is a clinic urgency and importance to identify prognostic factors for UVMs. Results: 55 aberrantly methylated sites of miRNAs and 47 aberrantly methylated sites of lncRNAs were observed between Alive < 2 years group and Alive > 2 years group of UVMs. Two prognostic classifiers were generated. For 13- miRNAs-CpG-classifier, the AUC were 0.958, 0.848 and 0.824 at 1 year, 2 years and 3 years, respectively. For 9- lncRNAs-CpG-classifier, the AUC were 0.943, 0.869 and 0.866 at 1 year, 2 years and 3 years, respectively. Conclusion: The correlation between genome-wide DNA methylation patterns of miRNAs and lncRNAs and the overall survival in UVMs were identified in this study. This novel finding shed new light on developing biomarkers of prognosis for UVMs. Methods: DNA methylation profiles of noncoding miRNAs and lncRNAs for UVMs were accessed from The Cancer Genome Atlas. Then the prognostic value was analyzed by least absolute shrinkage and selection operator method Cox regression and tested by Time-dependent Receiver Operating Characteristic curve.

Original languageEnglish (US)
Pages (from-to)6153-6174
Number of pages22
JournalAging
Volume11
Issue number16
DOIs
StatePublished - 2019
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by grants from the National Key Research and Development Program of China (2016YFE0107000) and the Wenzhou Science and Technology Bureau Project (Y20180171).

Publisher Copyright:
© Zheng et al.

Keywords

  • LncRNAs
  • Methylated panel
  • MiRNAs
  • Prognostic value
  • UVMs

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