Prognostic Value of C-Reactive Protein in Adults With Tuberculous Meningitis: A Prospective Cohort Study

Lillian Tugume; Fiona V. Cresswell; Nicole W. Engen; Asmus Tukundane; Sarah Kimuda; Timothy Mugabi; Suzan Namombwe; Enock Kagimu; Mable Kabahubya; Jayne Ellis; Nathan C. Bahr; David B. Meya; David R. Boulware

doi:10.1093/cid/ciaf261

Prognostic Value of C-Reactive Protein in Adults With Tuberculous Meningitis: A Prospective Cohort Study

Lillian Tugume
, Fiona V. Cresswell
, Nicole W. Engen
, Asmus Tukundane
, Sarah Kimuda
, Timothy Mugabi
, Suzan Namombwe
, Enock Kagimu
, Mable Kabahubya
, Jayne Ellis
, Nathan C. Bahr
, David B. Meya
, David R. Boulware

Research output: Contribution to journal › Article › peer-review

Abstract

We enrolled 135 adults with tuberculous meningitis (TBM), including 83% with HIV. Participants with baseline C-reactive protein (CRP) ≥40 mg/L had 3 times higher odds of an 8-week modified Rankin scale ≥4 (adjusted odds ratio, 2.78; 95% CI: 1.28–6.04; P =.010). CRP is a viable prognostic biomarker in TBM.

Original language	English (US)
Pages (from-to)	e410-e413
Journal	Clinical Infectious Diseases
Volume	81
Issue number	5
DOIs	https://doi.org/10.1093/cid/ciaf261
State	Published - Nov 15 2025

Bibliographical note

Publisher Copyright:
© The Author(s) 2025. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

Keywords

C-reactive protein
HIV
meningitis
tuberculosis
tuberculous meningitis

PubMed: MeSH publication types

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10.1093/cid/ciaf261

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Tugume, L., Cresswell, F. V., Engen, N. W., Tukundane, A., Kimuda, S., Mugabi, T., Namombwe, S., Kagimu, E., Kabahubya, M., Ellis, J., Bahr, N. C., Meya, D. B., & Boulware, D. R. (2025). Prognostic Value of C-Reactive Protein in Adults With Tuberculous Meningitis: A Prospective Cohort Study. Clinical Infectious Diseases, 81(5), e410-e413. https://doi.org/10.1093/cid/ciaf261

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title = "Prognostic Value of C-Reactive Protein in Adults With Tuberculous Meningitis: A Prospective Cohort Study",

abstract = "We enrolled 135 adults with tuberculous meningitis (TBM), including 83\% with HIV. Participants with baseline C-reactive protein (CRP) ≥40 mg/L had 3 times higher odds of an 8-week modified Rankin scale ≥4 (adjusted odds ratio, 2.78; 95\% CI: 1.28–6.04; P =.010). CRP is a viable prognostic biomarker in TBM.",

keywords = "C-reactive protein, HIV, meningitis, tuberculosis, tuberculous meningitis",

author = "Lillian Tugume and Cresswell, \{Fiona V.\} and Engen, \{Nicole W.\} and Asmus Tukundane and Sarah Kimuda and Timothy Mugabi and Suzan Namombwe and Enock Kagimu and Mable Kabahubya and Jayne Ellis and Bahr, \{Nathan C.\} and Meya, \{David B.\} and Boulware, \{David R.\}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2025. Published by Oxford University Press on behalf of Infectious Diseases Society of America.",

year = "2025",

month = nov,

day = "15",

doi = "10.1093/cid/ciaf261",

language = "English (US)",

volume = "81",

pages = "e410--e413",

journal = "Clinical Infectious Diseases",

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TY - JOUR

T1 - Prognostic Value of C-Reactive Protein in Adults With Tuberculous Meningitis

T2 - A Prospective Cohort Study

AU - Tugume, Lillian

AU - Cresswell, Fiona V.

AU - Engen, Nicole W.

AU - Tukundane, Asmus

AU - Kimuda, Sarah

AU - Mugabi, Timothy

AU - Namombwe, Suzan

AU - Kagimu, Enock

AU - Kabahubya, Mable

AU - Ellis, Jayne

AU - Bahr, Nathan C.

AU - Meya, David B.

AU - Boulware, David R.

PY - 2025/11/15

Y1 - 2025/11/15

N2 - We enrolled 135 adults with tuberculous meningitis (TBM), including 83% with HIV. Participants with baseline C-reactive protein (CRP) ≥40 mg/L had 3 times higher odds of an 8-week modified Rankin scale ≥4 (adjusted odds ratio, 2.78; 95% CI: 1.28–6.04; P =.010). CRP is a viable prognostic biomarker in TBM.

AB - We enrolled 135 adults with tuberculous meningitis (TBM), including 83% with HIV. Participants with baseline C-reactive protein (CRP) ≥40 mg/L had 3 times higher odds of an 8-week modified Rankin scale ≥4 (adjusted odds ratio, 2.78; 95% CI: 1.28–6.04; P =.010). CRP is a viable prognostic biomarker in TBM.

KW - C-reactive protein

KW - HIV

KW - meningitis

KW - tuberculosis

KW - tuberculous meningitis

UR - https://www.scopus.com/pages/publications/105025754610

UR - https://www.scopus.com/pages/publications/105025754610#tab=citedBy

U2 - 10.1093/cid/ciaf261

DO - 10.1093/cid/ciaf261

M3 - Article

C2 - 40581751

AN - SCOPUS:105025754610

SN - 1058-4838

VL - 81

SP - e410-e413

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 5

ER -

Prognostic Value of C-Reactive Protein in Adults With Tuberculous Meningitis: A Prospective Cohort Study

Abstract

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Keywords

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