Abstract
The aim of this study was to determine the prognostic effect of the absolute neutrophil count/absolute lymphocyte count ratio (ANC/ALC ratio) in patients with classic Hodgkin lymphoma (cHL). We performed a retrospective analysis of 312 patients with cHL. Univariate analysis revealed that a high ANC/ALC ratio (≥4.3) correlated with poor overall survival (OS) (P < .001). Subgroup analysis of advanced-stage disease showed that the ANC/ALC ratio was significant for OS (P = .032). Multivariate analysis revealed the ANC/ALC ratio to be an independent prognostic factor for OS (P = .048). The ANC/ALC ratio allowed further risk stratification in patients who were considered to be at low risk on the basis of an International Prognostic Score less than 4 (P = .002). The ANC/ALC ratio is a simple, inexpensive, and independent prognostic factor for OS that may improve the ability to identify high-risk patients with cHL.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 846-854 |
| Number of pages | 9 |
| Journal | American journal of clinical pathology |
| Volume | 138 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 2012 |
Keywords
- Hodgkin lymphoma
- Lymphocyte
- Neutrophil
- Neutrophil/lymphocyte ratio
- Prognosis
