TY - JOUR
T1 - Prognostic Indicators in Base of Tongue Adenocarcinoma
T2 - A Population-Based Analysis
AU - Kraimer, Kristen
AU - Ganti, Ashwin
AU - Plitt, Max A.
AU - Revenaugh, Peter
AU - Stenson, Kerstin
AU - Tajudeen, Bobby A.
AU - Al-Khudari, Samer
N1 - Publisher Copyright:
© The Author(s) 2019.
PY - 2021/9
Y1 - 2021/9
N2 - Introduction: The objectives of this investigation are to characterize the epidemiology of base of tongue adenocarcinoma utilizing a population-based database and to identify prognostic factors that may affect survival. Methods: A retrospective cohort study was conducted using the Surveillance, Epidemiology, and End Results database. Univariate Kaplan-Meier analysis and multivariate Cox-regression analysis were performed to evaluate the association of suspected prognostic factors with survival. Overall survival (OS) and disease-specific survival (DSS) were the primary outcome measures. Results: A total of 176 cases were eligible based on inclusion criteria. The 5-year OS and DSS were 49% and 66%, respectively. On multivariate analysis, surgical management was associated with improved OS and DSS (OS hazard ratio [HR]: 0.34, 95% confidence interval [CI]: 0.20-0.58, P <.001; DSS HR: 0.20, 95% CI: 0.09-0.48, P <.001), while higher tumor grade was associated with worse OS and DSS (OS HR: 1.58, 95% CI: 1.14-2.19, P =.006; DSS HR: 1.68, 95% CI: 1.01-2.79, P =.045). Administration of chemotherapy or radiation did not have a significant association with OS or DSS. Conclusion: This investigation is the largest to date to analyze the base of tongue adenocarcinoma as its own entity. Surgery remains the mainstay of treatment, and lower tumor grade is associated with improved survival in these patients. Administration of radiation or chemotherapy was not associated with improved survival.
AB - Introduction: The objectives of this investigation are to characterize the epidemiology of base of tongue adenocarcinoma utilizing a population-based database and to identify prognostic factors that may affect survival. Methods: A retrospective cohort study was conducted using the Surveillance, Epidemiology, and End Results database. Univariate Kaplan-Meier analysis and multivariate Cox-regression analysis were performed to evaluate the association of suspected prognostic factors with survival. Overall survival (OS) and disease-specific survival (DSS) were the primary outcome measures. Results: A total of 176 cases were eligible based on inclusion criteria. The 5-year OS and DSS were 49% and 66%, respectively. On multivariate analysis, surgical management was associated with improved OS and DSS (OS hazard ratio [HR]: 0.34, 95% confidence interval [CI]: 0.20-0.58, P <.001; DSS HR: 0.20, 95% CI: 0.09-0.48, P <.001), while higher tumor grade was associated with worse OS and DSS (OS HR: 1.58, 95% CI: 1.14-2.19, P =.006; DSS HR: 1.68, 95% CI: 1.01-2.79, P =.045). Administration of chemotherapy or radiation did not have a significant association with OS or DSS. Conclusion: This investigation is the largest to date to analyze the base of tongue adenocarcinoma as its own entity. Surgery remains the mainstay of treatment, and lower tumor grade is associated with improved survival in these patients. Administration of radiation or chemotherapy was not associated with improved survival.
KW - adenocarcinoma
KW - base of tongue
KW - population-based analysis
KW - SEER
UR - https://www.scopus.com/pages/publications/85074482180
UR - https://www.scopus.com/pages/publications/85074482180#tab=citedBy
U2 - 10.1177/0145561319881241
DO - 10.1177/0145561319881241
M3 - Article
C2 - 31619077
AN - SCOPUS:85074482180
SN - 0145-5613
VL - 100
SP - 467S-471S
JO - Ear, Nose and Throat Journal
JF - Ear, Nose and Throat Journal
IS - 5_suppl
ER -
