Prognostic implications of tumor extent in early-stage diffuse large B-cell lymphoma

Changhoon Yoo, Dok Hyun Yoon, Jeong Eun Kim, Jungmin Jo, Seong Joon Park, Shin Kyo Yoon, Yongchel Ahn, Shin Kim, Jooryung Huh, Dae Ho Lee, Cheolwon Suh

Research output: Contribution to journalArticlepeer-review

Abstract

Therapeutic strategies for early-stage diffuse large B-cell lymphoma (DLBCL) are often influenced by tumor extent, but the prognostic value of this parameter is rarely defined. Here, a retrospective analysis was performed to define the impact of tumor extent on survival of patients with early-stage DLBCL. Eighty-six patients with stage II DLBCL, diagnosed from 2000-2007, were categorized into localized (n = 55, 64 %) and disseminated groups (n = 31, 36 %) based on tumor extent at time of diagnosis. Treatment modalities, chemotherapy regimen and number of chemotherapy cycles were the same between groups. With a median follow-up of 7.6 years (range 2.1-12.1 years), overall 5-year event-free survival (EFS) and overall survival (OS) were 70.6 and 76.5 %, respectively. EFS (P = 1.00) and OS (P = 0.20) did not differ between the two groups. Older age (>60 years) was significantly associated with poor EFS (P = 0.01) and OS (P = 0.04). High-risk patients as rated by stage-modified international prognostic index (IPI) had inferior EFS (P = 0.04) and OS (P = 0.06) compared with the intermediate- risk group. These results indicate that tumor extent has no prognostic value in patients with early-stage DLBCL. Consistent with previous studies, age and stagemodified IPI were useful prognostic indices for these patients.

Original languageEnglish (US)
Pages (from-to)232-239
Number of pages8
JournalInternational Journal of Hematology
Volume97
Issue number2
DOIs
StatePublished - Feb 2013

Keywords

  • Diffuse large b-cell lymphoma
  • Disseminated
  • Localized
  • Prognosis
  • Tumor extent

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