Progesterone improves cognitive performance and attenuates smoking urges in abstinent smokers

Mehmet Sofuoglu; Maria Mouratidis; Marc E Mooney

doi:10.1016/j.psyneuen.2010.07.005

Progesterone improves cognitive performance and attenuates smoking urges in abstinent smokers

Mehmet Sofuoglu, Maria Mouratidis, Marc E Mooney

Psychology (Twin Cities)

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

Background: Progesterone, a steroid hormone, has been implicated in many CNS functions including reward, cognition, and neuroprotection. The goal of this study was to examine the dose-dependent effects of progesterone on cognitive performance, smoking urges, and smoking behavior in smokers. Methods: Thirty female and thirty-four male smokers participated in a double-blind, placebo-controlled study. Female smokers were in the early follicular phase of their menstrual cycle during study participation. Smokers were randomly assigned to either 200 or 400. mg/day of progesterone or placebo, given in two separate doses, during clinic visit. The first 3 days of the treatment period, smokers abstained from smoking, which was verified with breath CO levels. Smokers attended an experimental session on day 4 where the number of cigarettes smoked were recorded starting 2. h after the medication treatment. Results: Progesterone treatment, 200. mg/day, significantly improved cognitive performance in the Stroop and the Digit Symbol Substitution Test. Progesterone at 400. mg/day was associated with reduced urges for smoking but did not change ad lib smoking behavior. Conclusions: These findings suggest a potential therapeutic value of progesterone for smoking cessation.

Original language	English (US)
Pages (from-to)	123-132
Number of pages	10
Journal	Psychoneuroendocrinology
Volume	36
Issue number	1
DOIs	https://doi.org/10.1016/j.psyneuen.2010.07.005
State	Published - Jan 2011

Bibliographical note

Funding Information:
Dr. Mooney has received research grants from Pfizer Corporation. The remaining authors have no conflicts of interest to declare.

Funding Information:
This research was supported by the Veterans Administration Mental Illness Research, Education and Clinical Center (MIRECC) and the National Institute on Drug Abuse (NIDA) grants R01-DA 14537, K02-DA021304 (MS) and K01-DA-019446 (MM). The funding agencies had no further role in the study design; in the collection, analysis and interpretation of the data; in the writing of the report; and in the decision to submit the paper for publication.

Keywords

Cognitive performance
Menstrual cycle phase
Nicotine dependence
Progesterone
Sex differences

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.psyneuen.2010.07.005

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abstract = "Background: Progesterone, a steroid hormone, has been implicated in many CNS functions including reward, cognition, and neuroprotection. The goal of this study was to examine the dose-dependent effects of progesterone on cognitive performance, smoking urges, and smoking behavior in smokers. Methods: Thirty female and thirty-four male smokers participated in a double-blind, placebo-controlled study. Female smokers were in the early follicular phase of their menstrual cycle during study participation. Smokers were randomly assigned to either 200 or 400. mg/day of progesterone or placebo, given in two separate doses, during clinic visit. The first 3 days of the treatment period, smokers abstained from smoking, which was verified with breath CO levels. Smokers attended an experimental session on day 4 where the number of cigarettes smoked were recorded starting 2. h after the medication treatment. Results: Progesterone treatment, 200. mg/day, significantly improved cognitive performance in the Stroop and the Digit Symbol Substitution Test. Progesterone at 400. mg/day was associated with reduced urges for smoking but did not change ad lib smoking behavior. Conclusions: These findings suggest a potential therapeutic value of progesterone for smoking cessation.",

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author = "Mehmet Sofuoglu and Maria Mouratidis and Mooney, \{Marc E\}",

note = "Funding Information: Dr. Mooney has received research grants from Pfizer Corporation. The remaining authors have no conflicts of interest to declare. Funding Information: This research was supported by the Veterans Administration Mental Illness Research, Education and Clinical Center (MIRECC) and the National Institute on Drug Abuse (NIDA) grants R01-DA 14537, K02-DA021304 (MS) and K01-DA-019446 (MM). The funding agencies had no further role in the study design; in the collection, analysis and interpretation of the data; in the writing of the report; and in the decision to submit the paper for publication. ",

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N2 - Background: Progesterone, a steroid hormone, has been implicated in many CNS functions including reward, cognition, and neuroprotection. The goal of this study was to examine the dose-dependent effects of progesterone on cognitive performance, smoking urges, and smoking behavior in smokers. Methods: Thirty female and thirty-four male smokers participated in a double-blind, placebo-controlled study. Female smokers were in the early follicular phase of their menstrual cycle during study participation. Smokers were randomly assigned to either 200 or 400. mg/day of progesterone or placebo, given in two separate doses, during clinic visit. The first 3 days of the treatment period, smokers abstained from smoking, which was verified with breath CO levels. Smokers attended an experimental session on day 4 where the number of cigarettes smoked were recorded starting 2. h after the medication treatment. Results: Progesterone treatment, 200. mg/day, significantly improved cognitive performance in the Stroop and the Digit Symbol Substitution Test. Progesterone at 400. mg/day was associated with reduced urges for smoking but did not change ad lib smoking behavior. Conclusions: These findings suggest a potential therapeutic value of progesterone for smoking cessation.

AB - Background: Progesterone, a steroid hormone, has been implicated in many CNS functions including reward, cognition, and neuroprotection. The goal of this study was to examine the dose-dependent effects of progesterone on cognitive performance, smoking urges, and smoking behavior in smokers. Methods: Thirty female and thirty-four male smokers participated in a double-blind, placebo-controlled study. Female smokers were in the early follicular phase of their menstrual cycle during study participation. Smokers were randomly assigned to either 200 or 400. mg/day of progesterone or placebo, given in two separate doses, during clinic visit. The first 3 days of the treatment period, smokers abstained from smoking, which was verified with breath CO levels. Smokers attended an experimental session on day 4 where the number of cigarettes smoked were recorded starting 2. h after the medication treatment. Results: Progesterone treatment, 200. mg/day, significantly improved cognitive performance in the Stroop and the Digit Symbol Substitution Test. Progesterone at 400. mg/day was associated with reduced urges for smoking but did not change ad lib smoking behavior. Conclusions: These findings suggest a potential therapeutic value of progesterone for smoking cessation.

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KW - Menstrual cycle phase

KW - Nicotine dependence

KW - Progesterone

KW - Sex differences

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Progesterone improves cognitive performance and attenuates smoking urges in abstinent smokers

Abstract

Bibliographical note

Keywords

UN SDGs

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