Profoundly improved photostability of dimetronidazole by cocrystallization

Xinghui Hao, Jinhui Li, Chenguang Wang, Xinghua Zhao, Xin He, Changquan Calvin Sun

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Dimetronidazole (DMZ), an veterinary antibiotic, exhibits poor photostability with only 80.38% potency remaining after exposure to illuminance of 4500 lux for 7 days. The photodegradation is accompanied by obvious color change. A 1 : 1 cocrystal of DMZ with saccharine exhibited profoundly improved photostability with 98.95% of DMZ remaining after 7 days under the same light exposure. Thus, this new cocrystal can be used to develop more stable drug products of DMZ.

Original languageEnglish (US)
Pages (from-to)6165-6171
Number of pages7
JournalCrystEngComm
Volume24
Issue number35
DOIs
StatePublished - Aug 1 2022

Bibliographical note

Funding Information:
This work was financially supported by Key R&D Program of Hebei Province (No. 19227505D) and Educational Commission of Hebei Province of China (ZD2019109). We thank the Minnesota Supercomputing Institute44 at the University of Minnesota for providing the resources that contributed to the research results reported within this paper ( https://www.msi.umn.edu ). CCS thanks the National Science Foundation for support through the Industry University Collaborative Research Center grant IIP-2137264, Center for Integrated Materials Science and Engineering of Pharmaceutical Products (CIMSEPP).

Publisher Copyright:
© 2022 The Royal Society of Chemistry.

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