Profound Increase of Lung Airway Resistance in Heart Failure: a Potential Important Contributor for Dyspnea

Xiaohong Liu, Liuqing Yang, Dongmin Kwak, Lei Hou, Ruru Shang, Carolyn Meyer, Angela Panoskaltsis-Mortari, Xin Xu, Edward Kenneth Weir, Yingjie Chen

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Dyspnea is a major symptom of heart failure (HF). Here, we have studied the lung remodeling and airway resistance in HF mice. We demonstrated that aortic banding–induced HF caused a dramatic decrease of lung compliance and an increase of lung airway resistance. The decrease of lung compliance was correlated with the increased lung weight in a linear fashion (γ2 = 0.824). An HF-induced increase of lung airway resistance and a decrease of lung compliance were almost identical in anesthetized mice and in the isolated lungs from these mice. HF caused profound lung fibrosis in mice with increased lung weight. Moreover, HF patients of NYHA class III–IV showed increased lung density as revealed by high-resolution CT scanning. These data indicate that lung compliance and lung airway resistance may be useful in determining lung remodeling after HF, and lung structure changes may contribute to dyspnea in HF.

Original languageEnglish (US)
Pages (from-to)271-279
Number of pages9
JournalJournal of cardiovascular translational research
Issue number4
StatePublished - Aug 15 2019

Bibliographical note

Funding Information:
This study was supported by Grants R01HL105406 and HL139797-01A1 from the National Institutes of Health.

Publisher Copyright:
© 2019, Springer Science+Business Media, LLC, part of Springer Nature.


  • Heart failure
  • Lung compliance
  • Lung fibrosis
  • Pulmonary hypertension


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