Productive infection of T cells in lymphoid tissues during primary and early human immunodeficiency virus infection

Timothy Schacker, Susan Little, Elizabeth Connick, Kristin Gebhard, Zhi Qiang Zhang, John Krieger, Jon Pryor, Diane Havlir, Joseph K. Wong, Robert T. Schooley, Douglas Richman, Lawrence Corey, Ashley T. Haase

Research output: Contribution to journalArticlepeer-review

107 Scopus citations


Current models suggest that during human immunodeficiency virus type 1 (HIV-1) transmission virions are selected that use the CCR5 chemokine receptor on macrophages and/or dendritic cells. A gradual evolution to CXCR4 chemokine receptor use causes a shift in the proportion of productively infected cells to the CD4 cell population. Productively infected cells during acute and early infection in lymphoid tissue were assessed, as well as the impact of productive infection on the T cell population in 21 persons who had biopsies performed on days 2-280 after symptoms of acute HIV-1 seroconversion. Even in the earliest stages of infection, most productively infected cells were T lymphocytes. There were sufficient infected cells in lymphoid tissue (LT) to account for virus production and virus load in plasma. Despite the relatively high frequency of productively infected cells in LT, the impact on the size of the T cell population in LT at this stage was minor.

Original languageEnglish (US)
Pages (from-to)555-562
Number of pages8
JournalJournal of Infectious Diseases
Issue number4
StatePublished - Feb 15 2001

Bibliographical note

Funding Information:
Financial support: National Institutes of Health (AI-28246, AI-30731, AI-01338, AI-38858, AI-43638, AI-27670, AI-36214, and AI-29164); AIDS Clinical Trials Group (2-U01-A127664-06).


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