Production of Achlorhydria in Rats by Direct Irradiation of the Stomach

M. John Murray, Nell Stein, John Mathews, Rita Deyo

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Lasting achlorhydria was produced in rats by irradiation of the exposed stomach. Gastric pH determination in the living animal correlates well with the degree of impairment of gastric acid secretion induced by irradiation. Rats treated in this way provide a good experimental model comparable to an animal with total gastrectomy but without the disadvantage of an interrupted gut.

Original languageEnglish (US)
Pages (from-to)737-739
Number of pages3
JournalProceedings of the Society for Experimental Biology and Medicine
Volume131
Issue number3
DOIs
StatePublished - Jul 1969

Bibliographical note

Funding Information:
Supported by the John Hartford Foundation and by the National Institute of Arthritis and Metabolic Disease Research Grant No. AM 10976-01. 7 1969 131 3 737 739

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