Producción de (+)-discodermólido por la esponja Discodermia dissoluta bajo sistemas de cultivo fijo y suspendido

Translated title of the contribution: Production of (+)-discodermolide by the sponge Discodermia dissoluta under fixed and suspended culture systems

Javier Gomez-León, Johann Lopez-Navarro, Alicia Millanguir, Jesus David Castaño, Sven Zea

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The macrolide (+)-discodermolide produced by the marine sponge Discodermia dissoluta shows promising antitumor, antimitotic,and immunosuppressive activity. However, the sustainable supply of any molecule requires much in situ and in vitro research to optimize and later obtain the molecule of interest. In this study, two culture systems—fixed and suspended—were evaluated at 15-m depth in two sites, Punta de Betín and Nenguange, in Santa Marta (Colombian Caribbean). Survival, growth, and production of (+)-discodermolide were recorded, with the suspended system resulting in better growth and survival, depending on the culture site. The influence of the different environmental factors on survival was also studied, and a negative correlation with temperature was observed. Salinity, solar radiation, organic matter, and water flow were not correlated. Finally, no significant differences in the production of (+)-discodermolide existed between the culture systems and study sites. Production ranged from 20 to 270 μg per gram of dry sponge.

Translated title of the contributionProduction of (+)-discodermolide by the sponge Discodermia dissoluta under fixed and suspended culture systems
Original languageSpanish
Pages (from-to)153-174
Number of pages22
JournalBoletin de Investigaciones Marinas y Costeras
Issue number2
StatePublished - 2017
Externally publishedYes

Bibliographical note

Funding Information:
The authors are grateful for the financial support from the Departamento Administrativo de Ciencia, Tecnología e Innovación – Colciencias (Administrative Department of Science, Technology and Innovation) under contract RC No. 327-2011. The authors acknowledge the Instituto de Investigaciones Marinas y Costeras (Institute of Marine and Coastal Research – Contribution N° 1164) “José Benito Vives De Andréis”-Invemar; the Universidad Nacional de Colombia Sede Caribe (National University of Colombia, Caribbean); and the Ministerio de Ambiente y Desarrollo Sostenible -MADS (Ministry of Environment and Sustainable Development), which through the Banco de Proyectos de Inversión Nacional –BPIN (Bank of National Investment Projects) financed the present project PRY-VAR-006-011. Additionally, the authors acknowledge the Línea de Bioprospección Marina del Programa de Valoración y Aprovechamiento de los Recursos Marinos (Marine Bioprospection Division of the Program for the Evaluation and Use of Marine and Coastal Resources), where the project was carried out, and especially thank Carlos Puentes for the quantification of (+)-discodermolide. Sven Zea’s work is contribution 466 of Instituto de Estudios en Ciencias del Mar—CECIMAR, Universidad Nacional de Colombia, Sede Caribe.


  • (+)-discodermolide
  • Aquaculture
  • Discodermia dissoluta
  • Sponge culture
  • Sponge fragments


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