Proctitis after conventional external radiation therapy for prostate cancer: Importance of minimizing posterior rectal dose

Kwan H. Cho, Chung K.K. Lee, Seymour H. Levitt

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

PURPOSE: To identify factors associated with the prevalence of radiation proctitis in patients with prostate cancer treated with external radiation therapy and to determine if a dose-response relationship exists. MATERIALS AND METHODS: The study included 101 prostate cancer patients treated at the University of Minnesota Hospital and Clinics between 1970 and 1987. Radiation therapy at a daily dose of 175-200 cGy was given for 5 consecutive days per week for 7 weeks with a 10-24-MV linear accelerator. Mean dose to the prostate was 6,795 cGy (range, 5,579-7,417 cGy). Simulation radiographs obtained with rectal barium were analyzed in 51 patients. Doses were calculated at specific points in the boost field. RESULTS: Radiation proctitis developed in 19 patients. No pretreatment or treatment factors were associated with a higher prevalence of proctitis. Statistically significant correlation (P < .042) was found between the development of proctitis and dose to the posterior rectum. At χ2 analysis, proctitis was statistically significantly (P < .005) associated with posterior rectal doses of >5,000 cGy. CONCLUSION: A high posterior rectal dose (>5,000 cGy) is associated with increased prevalence of proctitis after radiation therapy.

Original languageEnglish (US)
Pages (from-to)699-703
Number of pages5
JournalRadiology
Volume195
Issue number3
DOIs
StatePublished - Jun 1995

Keywords

  • Prostate, neoplasms
  • Prostate, therapeutic radiology
  • Rectum, therapeutic radiology
  • Therapeutic radiology

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