Process of care and outcomes in patients with peripheral arterial disease

Tracie C. Collins, Rebecca J. Beyth, David B. Nelson, Nancy J. Petersen, Maria E. Suarez-Almazor, Ruth L. Bush, Alan T. Hirsch, Carol M. Ashton

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

BACKGROUND: We investigated the association of process of care measures with adverse limb and systemic events in patients with peripheral arterial disease (PAD). METHODS: We conducted a retrospective cohort study of patients with PAD, as defined by an ankle-brachial index (ABI) <0.9. The index date was defined as the date, during 1995 to 1998, when the patient was seen in the Michael E. DeBakey VA Medical Center noninvasive vascular laboratory and found to have PAD. We conducted a chart review for process of care variables starting 3 years before the index date and ending at the time of the first event or the final visit (December 31, 2001), whichever occurred first. We examined the association between PAD process of care measures, including risk factor control, and prescribing of medication, with time of the patient's first major limb event or death. RESULTS: Of the 796 patients (mean age, 65±9.9 years), 230 (28.9% experienced an adverse limb event (136 lower-extremity bypass, 94 lower-extremity amputation), and 354 (44.5%) died. Of the patients who died, 247 died without a preceding limb event. Glucose control was protective against death or a limb event with a hazard ratio (HR) of 0.74 (95% confidence limits [CL] 0.60, 0.91, P=0.004). African Americans were at 2.8 (95% CL 1.7, 4.5) times the risk of Whites or Hispanics for an adverse limb event. However, this risk was no longer significant if their glucose was controlled. For process measures, the dispensing of PAD specific medication (HR 1.4, 95% CL 1.1, 1.7) was associated an increased risk for an adverse outcome. CONCLUSIONS: Our data suggest that glucose control is key to reducing the risk for adverse outcomes, particularly limb events in African Americans. Certain process of care measures, as markers of disease severity and disease management, are associated with poor outcomes in patients with PAD. Further work is needed to determine the role of early disease intervention to reduce poor outcomes in patients with PAD.

Original languageEnglish (US)
Pages (from-to)942-948
Number of pages7
JournalJournal of general internal medicine
Volume22
Issue number7
DOIs
StatePublished - Jul 2007

Bibliographical note

Funding Information:
Acknowledgments: This work was supported by an Investigator-Initiated Grant (#01-180-1; Principal Investigator, Dr. Tracie C. Collins) from the Department of Veterans Affairs, Health Services Research and Development, along with resources from the Houston Center for Quality of Care and Utilization Studies, Michael E. DeBakey Veterans Affairs Medical Center. Dr. Collins was a recipient of the Department of Veterans Affairs Advanced Clinical Research Career Development Award. Dr. Beyth was a recipient of the Department of Veterans Affairs HSR&D Advanced Research Career Development Award during data collection for this work. We acknowledge and are very grateful for the excellent study support by Patricia N. Krueger, Meei Ku-Goto, and Diana Urbauer.

Keywords

  • Atherosclerosis risk factors
  • Glucose control
  • Peripheral arterial disease
  • Process of care
  • Surgery

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