Abstract
The Seventh Annual Deep Brain Stimulation (DBS) Think Tank held on September 8th of 2019 addressed the most current: (1) use and utility of complex neurophysiological signals for development of adaptive neurostimulation to improve clinical outcomes; (2) Advancements in recent neuromodulation techniques to treat neuropsychiatric disorders; (3) New developments in optogenetics and DBS; (4) The use of augmented Virtual reality (VR) and neuromodulation; (5) commercially available technologies; and (6) ethical issues arising in and from research and use of DBS. These advances serve as both “markers of progress” and challenges and opportunities for ongoing address, engagement, and deliberation as we move to improve the functional capabilities and translational value of DBS. It is in this light that these proceedings are presented to inform the field and initiate ongoing discourse. As consistent with the intent, and spirit of this, and prior DBS Think Tanks, the overarching goal is to continue to develop multidisciplinary collaborations to rapidly advance the field and ultimately improve patient outcomes.
| Original language | English (US) |
|---|---|
| Article number | 54 |
| Journal | Frontiers in Human Neuroscience |
| Volume | 14 |
| DOIs | |
| State | Published - Mar 27 2020 |
| Externally published | Yes |
Bibliographical note
Funding Information:AR-Z acknowledges research support by Thomas and Carole Miller. JA acknowledges all the research groups that presented and attended this edition of DBS Think Tank. WG acknowledges collaborators including David Brocker, Isaac Cassar, Karthik Kumaravelu, Jaydeep Sambangi, Steve Schmidt, Chunxiu “Traci” Yu, and Dennis Turner. NS and WT acknowledge their clinical team – Kristian Bulluss and San San Xu – and engineering team – Hugh McDermott, Wee-Lih Lee, Thushara Perera, James Fallon, Nicola Acevedo and Angus Begg. AB acknowledges technical support provided by Polina Lyuboslavsky, Meredith McCarty, Aurora Weiden, and Madelynne Campbell. GS acknowledges among the many contributors to the INSHAPE study Prof. Bart Nuttin, Prof. Myles Mc Laughlin, Dr. Alexandra Boogers, PhD student, Jana Peeters, PhD student. All other authors report no acknowledgments. Funding. JGi’s work is supported in part by CSCI, the Henry M. Jackson Foundation for Military Medicine; Leadership Initiatives; and federal funds UL1TR001409 from the National Center for Advancing Translational Sciences (NCATS), National Institutes of Health, through the Clinical and Translational Science Awards Program (CTSA), a trademark of the Department of Health and Human Services, part of the Roadmap Initiative, “Re-Engineering the Clinical Research Enterprise.” AG acknowledges funding from the NSF PECASE 1553482, NIH R01 NS096008, NIH UH3 NS95553. JA reports funding from the Graduate School Preeminence Award NIH NINDS UH3. SC reports funding by the T32 National Institutes of Health, National Institute of Neurological Disorders and Stroke Grant T32NS082128. JGo reports funding from the Fulbright Scholar, cohort 2018-2020. However, Fulbright didn’t have a role in the study. SL received funding from the National Center for Advancing Translational Sciences (TL1 TR001428). WG’s work was supported by NIH R37 NS040894, R01 NS091236 and UH3 NS103468. HW receives research funding from the National Institutes of Health (UH3 NS100553), the Michael J. Fox Foundation (MJFF 15098), and funding for fellowship training from Medtronic. NS and WT acknowledge funding support by the Colonial Foundation, St Vincent’s Hospital Research Endowment Fund, and the National Health and Medical Research Council (project grant #1103238, development grant #1113680), and support to the Bionics Institute from the Victorian Government through its operational infrastructure program. WT is supported by Lions International and the National Health and Medical Research Council. NS is supported through an Australian Government Research Training Program Scholarship. SS reports funding NIH UH3 NS103549. KS acknowledges funding from the National Institutes of Health award K23NS110962 NARSAD Young Investigator grant from the Brain and Behavioral Research Foundation, Ray and Dagmar Dolby Family Fund through the Department of Psychiatry at the University of California, San Francisco. AB reports funding from NIH/NINDS, K08 NS094643 Child Neurology Foundation, Pediatric Epilepsy Research Foundation (PERF) Scientific Research Grant University of Texas System Rising STARs Award University of Texas at Austin startup funds. PR acknowledges funding from the NIMH R00MH109652. NS reports funding from the National Institute of Neurological Disorders and Stroke (NS103802), the McKnight Foundation (Technological Innovations in Neuroscience Award), and the W.M. Keck Foundation. KC acknowledges that some of the research reported in this article was funded by the National Institute of Neurological Disorders and Stroke, Award Number RC1NS068086 and the National Institute of Mental Health, Award Number R01MH114853. The content is solely the responsibility of the author and does not necessarily represent the official views of the National Institute of Neurological Disorders and Stroke, National Institute of Mental Health, or the National Institutes of Health. LRS reports funding from National Institutes of Health (NIH) grant number 1F32MH115419-01. GS reports funding for the INSHAPE study was provided by Boston Scientific Neuromodulation. MO’s DBS research is supported by NIH R01 NR014852 and R01NS096008. All other authors indicate no funding sources pertinent to this work.
Funding Information:
JGi’s work is supported in part by CSCI, the Henry M. Jackson Foundation for Military Medicine; Leadership Initiatives; and federal funds UL1TR001409 from the National Center for Advancing Translational Sciences (NCATS), National Institutes of Health, through the Clinical and Translational Science Awards Program (CTSA), a trademark of the Department of Health and Human Services, part of the Roadmap Initiative, ‘‘Re-Engineering the Clinical Research Enterprise.’’ AG acknowledges funding from the NSF PECASE 1553482, NIH R01 NS096008, NIH UH3 NS95553. JA reports funding from the Graduate School Preeminence Award NIH NINDS UH3. SC reports funding by the T32 National Institutes of Health, National Institute of Neurological Disorders and Stroke Grant T32NS082128. JGo reports funding from the Fulbright Scholar, cohort 2018-2020. However, Fulbright didn’t have a role in the study. SL received funding from the National Center for Advancing Translational Sciences (TL1 TR001428). WG’s work was supported by NIH R37 NS040894, R01 NS091236 and UH3 NS103468. HW receives research funding from the National Institutes of Health (UH3 NS100553), the Michael J. Fox Foundation (MJFF 15098), and funding for fellowship training from Medtronic. NS and WT acknowledge funding support by the Colonial Foundation, St Vincent’s Hospital Research Endowment Fund, and the National Health and Medical Research Council (project grant #1103238, development grant #1113680), and support to the Bionics Institute from the Victorian Government through its operational infrastructure program. WT is supported by Lions International and the National Health and Medical Research Council. NS is supported through an Australian Government Research Training Program Scholarship. SS reports funding NIH UH3 NS103549. KS acknowledges funding from the National Institutes of Health award K23NS110962 NARSAD Young Investigator grant from the Brain and Behavioral Research Foundation, Ray and Dagmar Dolby Family Fund through the Department of Psychiatry at the University of California, San Francisco. AB reports funding from NIH/NINDS, K08 NS094643 Child Neurology Foundation, Pediatric Epilepsy Research Foundation (PERF) Scientific Research Grant University of Texas System Rising STARs Award University of Texas at Austin startup funds. PR acknowledges funding from the NIMH R00MH109652. NS reports funding from the National Institute of Neurological Disorders and Stroke (NS103802), the McKnight Foundation (Technological Innovations in Neuroscience Award), and the W.M. Keck Foundation. KC acknowledges that some of the research reported in this article was funded by the National Institute of Neurological Disorders and Stroke, Award Number RC1NS068086 and the National Institute of Mental Health, Award Number R01MH114853. The content is solely the responsibility of the author and does not necessarily represent the official views of the National Institute of Neurological Disorders and Stroke, National Institute of Mental Health, or the National Institutes of Health. LRS reports funding from National Institutes of Health (NIH) grant number 1F32MH115419-01. GS reports funding for the INSHAPE study was provided by Boston Scientific Neuromodulation. MO’s DBS research is supported by NIH R01 NR014852 and R01NS096008. All other authors indicate no funding sources pertinent to this work.
Publisher Copyright:
© Copyright © 2020 Ramirez-Zamora, Giordano, Gunduz, Alcantara, Cagle, Cernera, Difuntorum, Eisinger, Gomez, Long, Parks, Wong, Chiu, Patel, Grill, Walker, Little, Gilron, Tinkhauser, Thevathasan, Sinclair, Lozano, Foltynie, Fasano, Sheth, Scangos, Sanger, Miller, Brumback, Rajasethupathy, McIntyre, Schlachter, Suthana, Kubu, Sankary, Herrera-Ferrá, Goetz, Cheeran, Steinke, Hess, Almeida, Deeb, Foote and Okun.
Keywords
- deep brain stimulation
- depression
- local field potentials
- neuroethics
- optogenetics
- Parkinson’s disease
- stereoelectroencephalography
- tremor
