Proceedings of the Second Annual Deep Brain Stimulation Think Tank: What's in the Pipeline

Aysegul Gunduz; Hokuto Morita; P. Justin Rossi; William L. Allen; Ron L. Alterman; Helen Bronte-Stewart; Christopher R. Butson; David Charles; Sjaak Deckers; Coralie De Hemptinne; Mahlon Delong; Darin Dougherty; Jens Ellrich; Kelly D. Foote; James Giordano; Wayne Goodman; Benjamin D. Greenberg; David Greene; Robert Gross; Jack W. Judy; Edward Karst; Alexander Kent; Brian Kopell; Anthony Lang; Andres Lozano; Codrin Lungu; Kelly E. Lyons; Andre MacHado; Hubert Martens; Cameron McIntyre; Hoon Ki Min; Joseph Neimat; Jill Ostrem; Sat Pannu; Francisco Ponce; Nader Pouratian; Donnie Reymers; Lauren Schrock; Sameer Sheth; Ludy Shih; Scott Stanslaski; G. Karl Steinke; Paul Stypulkowski; Alexander I. Troster; Leo Verhagen; Harrison Walker; Michael S. Okun

doi:10.3109/00207454.2014.999268

Proceedings of the Second Annual Deep Brain Stimulation Think Tank: What's in the Pipeline

Aysegul Gunduz, Hokuto Morita, P. Justin Rossi, William L. Allen, Ron L. Alterman, Helen Bronte-Stewart, Christopher R. Butson, David Charles, Sjaak Deckers, Coralie De Hemptinne, Mahlon Delong, Darin Dougherty, Jens Ellrich, Kelly D. Foote, James Giordano, Wayne Goodman, Benjamin D. Greenberg, David Greene, Robert Gross, Jack W. JudyEdward Karst, Alexander Kent, Brian Kopell, Anthony Lang, Andres Lozano, Codrin Lungu, Kelly E. Lyons, Andre MacHado, Hubert Martens, Cameron McIntyre, Hoon Ki Min, Joseph Neimat, Jill Ostrem, Sat Pannu, Francisco Ponce, Nader Pouratian, Donnie Reymers, Lauren Schrock, Sameer Sheth, Ludy Shih, Scott Stanslaski, G. Karl Steinke, Paul Stypulkowski, Alexander I. Troster, Leo Verhagen, Harrison Walker, Michael S. Okun

Neurology

Research output: Contribution to journal › Review article › peer-review

10 Scopus citations

Abstract

The proceedings of the 2nd Annual Deep Brain Stimulation Think Tank summarize the most contemporary clinical, electrophysiological, and computational work on DBS for the treatment of neurological and neuropsychiatric disease and represent the insights of a unique multidisciplinary ensemble of expert neurologists, neurosurgeons, neuropsychologists, psychiatrists, scientists, engineers and members of industry. Presentations and discussions covered a broad range of topics, including advocacy for DBS, improving clinical outcomes, innovations in computational models of DBS, understanding of the neurophysiology of Parkinson's disease (PD) and Tourette syndrome (TS) and evolving sensor and device technologies.

Original language	English (US)
Pages (from-to)	475-485
Number of pages	11
Journal	International Journal of Neuroscience
Volume	125
Issue number	7
DOIs	https://doi.org/10.3109/00207454.2014.999268
State	Published - Jul 3 2015

Bibliographical note

Funding Information:
AG: Grant support from Medtronic, Inc.; HK: None; PJR: None; WLA: None; RLA: Consultant for Medtronic, Inc.; HB-S: None; CRB: Consultant for St Jude Medical, Boston Scientific; IP related to DBS; DC: Vanderbilt receives income from grants or contracts from Allergan, Ipsen, Merz and Medtronic for research led by DC; DC receives income from Allergan, Ipsen, Medtronic and, the Alliance for Patient Access for education or consulting services; SD: Employee and shareholder of Sapiens Steering Brain Stimulation GmbH (Medtronic Eindhoven Design Center); CDH: None; MDL: None; DD: Grant support from Medtronic, Cyberonics, Eli Lilly, Roche, Honoraria from Medtronic, Insys, Johnson & Johnson; JE: Chief Medical Officer at Sapiens Steering Brain Stimulation GmbH; KDF: Grant support from Medtronic, St. Jude, Boston Scientific, Neuropace; Consultant for Medtronic, Neuropace; JG: None; WG: None; BDG: None; DG: Employee of Neuropace; RG: None; JJ: None; EK: Employee of St. Jude Medical; AK: Employee of St. Jude Medical; BK: Consultant for Medtronic, St Jude Neuromodulation, MRI Interventions; ALang: Consultant for Abbvie, Allon Therapeutics, Avanir Pharmaceuticals, Biogen Idec, Boerhinger-Ingelheim, Ceregene, Lilly, Medtronic, Merck, Novartis, NeuroPhage Pharmaceuticals, Teva, UCB; Honoraria from Medtronic, Teva, UCB, AbbVie; Grant support from Brain Canada, Canadian Institutes of Health Research, Edmond J Safra Philanthropic Foundation, Michael J. Fox Foundation, the Ontario Brain Institute, National Parkinson Foundation, Parkinson Society Canada, Tourette Syndrome Association, W. Garfield Weston Foundation; Publishing royalties from Saunders, Wiley-Blackwell, Johns Hopkins Press, Cambridge University Press; ALozano: Consultant for Medtronic, St Jude and Boston Scientific, Co-Founder of Functional Neuromodulation; CL: None; KL: Consultant for Medtronic, St. Jude Medical; AM: IP in Enspire, ATI, Cardionomics, Grant support from Medtronic, Inc., Consultant for Functional Neuro-modulation, Spinal Modulation; HM: Employee and shareholder of Sapiens Steering Brain Stimulation GmbH (Medtronic Eindhoven Design Center); CM: IP in Boston Scientific Neuromodulation; Consultant for Boston Scientific Neuromodulation; Shareholder in Autonomic Technologies, Inc., Cardionomics, Inc., Neuros Medical, Inc., Surgical Information Sciences, Inc.; BM: None; HKM: None; JN: Grant support from Medtronic, Inc.; Consultant for Medtronic, Inc., Mon-teris Inc.; JO: Grant support from Boston Scientific, MRI Interventions, St Jude Medical, Medtronic; SP: None; FP: Consultant for Medtronic, Inc; NP: None; DR: Employee of Neuromodulation, Inc; LSchrock: Site PI for the Boston Scientific INTREPID DBS trial; SSheth: None; LShih: None; SStanslanski: Employee of Medtronic, Inc.; GKS: Employee of Boston Scientific Neuromodulation; PS: Employee of Medtronic, Inc.; AT: Consultant for St Jude Medical, Boston Scientific, Theravance, Teva; Grant support from Glaxo Smith Kone, Speaker for Medtronic; Royalties from Oxford University Press; LV: None; HW: None; MSO: Consultant for National Parkinson Foundation; Grant support from NIH, NPF, Michael J. Fox Foundation, Parkinson Alliance, Smallwood Foundation, Bachmann-Strauss Foundation, Tourette Syndrome Association, UF Foundation.

Publisher Copyright:
© 2015 The Authors.

Keywords

Deep brain stimulation
Electrophysiology
Movement disorders
Neuroethics
neurotechnology

Publisher link

10.3109/00207454.2014.999268

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Gunduz, A., Morita, H., Rossi, P. J., Allen, W. L., Alterman, R. L., Bronte-Stewart, H., Butson, C. R., Charles, D., Deckers, S., De Hemptinne, C., Delong, M., Dougherty, D., Ellrich, J., Foote, K. D., Giordano, J., Goodman, W., Greenberg, B. D., Greene, D., Gross, R., ... Okun, M. S. (2015). Proceedings of the Second Annual Deep Brain Stimulation Think Tank: What's in the Pipeline. International Journal of Neuroscience, 125(7), 475-485. https://doi.org/10.3109/00207454.2014.999268

Gunduz, A, Morita, H, Rossi, PJ, Allen, WL, Alterman, RL, Bronte-Stewart, H, Butson, CR, Charles, D, Deckers, S, De Hemptinne, C, Delong, M, Dougherty, D, Ellrich, J, Foote, KD, Giordano, J, Goodman, W, Greenberg, BD, Greene, D, Gross, R, Judy, JW, Karst, E, Kent, A, Kopell, B, Lang, A, Lozano, A, Lungu, C, Lyons, KE, MacHado, A, Martens, H, McIntyre, C, Min, HK, Neimat, J, Ostrem, J, Pannu, S, Ponce, F, Pouratian, N, Reymers, D, Schrock, L, Sheth, S, Shih, L, Stanslaski, S, Steinke, GK, Stypulkowski, P, Troster, AI, Verhagen, L, Walker, H & Okun, MS 2015, 'Proceedings of the Second Annual Deep Brain Stimulation Think Tank: What's in the Pipeline', International Journal of Neuroscience, vol. 125, no. 7, pp. 475-485. https://doi.org/10.3109/00207454.2014.999268

@article{5590906c471048f8b1e1347253ffa024,

title = "Proceedings of the Second Annual Deep Brain Stimulation Think Tank: What's in the Pipeline",

abstract = "The proceedings of the 2nd Annual Deep Brain Stimulation Think Tank summarize the most contemporary clinical, electrophysiological, and computational work on DBS for the treatment of neurological and neuropsychiatric disease and represent the insights of a unique multidisciplinary ensemble of expert neurologists, neurosurgeons, neuropsychologists, psychiatrists, scientists, engineers and members of industry. Presentations and discussions covered a broad range of topics, including advocacy for DBS, improving clinical outcomes, innovations in computational models of DBS, understanding of the neurophysiology of Parkinson's disease (PD) and Tourette syndrome (TS) and evolving sensor and device technologies.",

keywords = "Deep brain stimulation, Electrophysiology, Movement disorders, Neuroethics, neurotechnology",

author = "Aysegul Gunduz and Hokuto Morita and Rossi, {P. Justin} and Allen, {William L.} and Alterman, {Ron L.} and Helen Bronte-Stewart and Butson, {Christopher R.} and David Charles and Sjaak Deckers and {De Hemptinne}, Coralie and Mahlon Delong and Darin Dougherty and Jens Ellrich and Foote, {Kelly D.} and James Giordano and Wayne Goodman and Greenberg, {Benjamin D.} and David Greene and Robert Gross and Judy, {Jack W.} and Edward Karst and Alexander Kent and Brian Kopell and Anthony Lang and Andres Lozano and Codrin Lungu and Lyons, {Kelly E.} and Andre MacHado and Hubert Martens and Cameron McIntyre and Min, {Hoon Ki} and Joseph Neimat and Jill Ostrem and Sat Pannu and Francisco Ponce and Nader Pouratian and Donnie Reymers and Lauren Schrock and Sameer Sheth and Ludy Shih and Scott Stanslaski and Steinke, {G. Karl} and Paul Stypulkowski and Troster, {Alexander I.} and Leo Verhagen and Harrison Walker and Okun, {Michael S.}",

note = "Funding Information: AG: Grant support from Medtronic, Inc.; HK: None; PJR: None; WLA: None; RLA: Consultant for Medtronic, Inc.; HB-S: None; CRB: Consultant for St Jude Medical, Boston Scientific; IP related to DBS; DC: Vanderbilt receives income from grants or contracts from Allergan, Ipsen, Merz and Medtronic for research led by DC; DC receives income from Allergan, Ipsen, Medtronic and, the Alliance for Patient Access for education or consulting services; SD: Employee and shareholder of Sapiens Steering Brain Stimulation GmbH (Medtronic Eindhoven Design Center); CDH: None; MDL: None; DD: Grant support from Medtronic, Cyberonics, Eli Lilly, Roche, Honoraria from Medtronic, Insys, Johnson & Johnson; JE: Chief Medical Officer at Sapiens Steering Brain Stimulation GmbH; KDF: Grant support from Medtronic, St. Jude, Boston Scientific, Neuropace; Consultant for Medtronic, Neuropace; JG: None; WG: None; BDG: None; DG: Employee of Neuropace; RG: None; JJ: None; EK: Employee of St. Jude Medical; AK: Employee of St. Jude Medical; BK: Consultant for Medtronic, St Jude Neuromodulation, MRI Interventions; ALang: Consultant for Abbvie, Allon Therapeutics, Avanir Pharmaceuticals, Biogen Idec, Boerhinger-Ingelheim, Ceregene, Lilly, Medtronic, Merck, Novartis, NeuroPhage Pharmaceuticals, Teva, UCB; Honoraria from Medtronic, Teva, UCB, AbbVie; Grant support from Brain Canada, Canadian Institutes of Health Research, Edmond J Safra Philanthropic Foundation, Michael J. Fox Foundation, the Ontario Brain Institute, National Parkinson Foundation, Parkinson Society Canada, Tourette Syndrome Association, W. Garfield Weston Foundation; Publishing royalties from Saunders, Wiley-Blackwell, Johns Hopkins Press, Cambridge University Press; ALozano: Consultant for Medtronic, St Jude and Boston Scientific, Co-Founder of Functional Neuromodulation; CL: None; KL: Consultant for Medtronic, St. Jude Medical; AM: IP in Enspire, ATI, Cardionomics, Grant support from Medtronic, Inc., Consultant for Functional Neuro-modulation, Spinal Modulation; HM: Employee and shareholder of Sapiens Steering Brain Stimulation GmbH (Medtronic Eindhoven Design Center); CM: IP in Boston Scientific Neuromodulation; Consultant for Boston Scientific Neuromodulation; Shareholder in Autonomic Technologies, Inc., Cardionomics, Inc., Neuros Medical, Inc., Surgical Information Sciences, Inc.; BM: None; HKM: None; JN: Grant support from Medtronic, Inc.; Consultant for Medtronic, Inc., Mon-teris Inc.; JO: Grant support from Boston Scientific, MRI Interventions, St Jude Medical, Medtronic; SP: None; FP: Consultant for Medtronic, Inc; NP: None; DR: Employee of Neuromodulation, Inc; LSchrock: Site PI for the Boston Scientific INTREPID DBS trial; SSheth: None; LShih: None; SStanslanski: Employee of Medtronic, Inc.; GKS: Employee of Boston Scientific Neuromodulation; PS: Employee of Medtronic, Inc.; AT: Consultant for St Jude Medical, Boston Scientific, Theravance, Teva; Grant support from Glaxo Smith Kone, Speaker for Medtronic; Royalties from Oxford University Press; LV: None; HW: None; MSO: Consultant for National Parkinson Foundation; Grant support from NIH, NPF, Michael J. Fox Foundation, Parkinson Alliance, Smallwood Foundation, Bachmann-Strauss Foundation, Tourette Syndrome Association, UF Foundation. Publisher Copyright: {\textcopyright} 2015 The Authors.",

year = "2015",

month = jul,

day = "3",

doi = "10.3109/00207454.2014.999268",

language = "English (US)",

volume = "125",

pages = "475--485",

journal = "International Journal of Neuroscience",

issn = "0020-7454",

publisher = "Informa Healthcare",

number = "7",

}

TY - JOUR

T1 - Proceedings of the Second Annual Deep Brain Stimulation Think Tank

T2 - What's in the Pipeline

AU - Gunduz, Aysegul

AU - Morita, Hokuto

AU - Rossi, P. Justin

AU - Allen, William L.

AU - Alterman, Ron L.

AU - Bronte-Stewart, Helen

AU - Butson, Christopher R.

AU - Charles, David

AU - Deckers, Sjaak

AU - De Hemptinne, Coralie

AU - Delong, Mahlon

AU - Dougherty, Darin

AU - Ellrich, Jens

AU - Foote, Kelly D.

AU - Giordano, James

AU - Goodman, Wayne

AU - Greenberg, Benjamin D.

AU - Greene, David

AU - Gross, Robert

AU - Judy, Jack W.

AU - Karst, Edward

AU - Kent, Alexander

AU - Kopell, Brian

AU - Lang, Anthony

AU - Lozano, Andres

AU - Lungu, Codrin

AU - Lyons, Kelly E.

AU - MacHado, Andre

AU - Martens, Hubert

AU - McIntyre, Cameron

AU - Min, Hoon Ki

AU - Neimat, Joseph

AU - Ostrem, Jill

AU - Pannu, Sat

AU - Ponce, Francisco

AU - Pouratian, Nader

AU - Reymers, Donnie

AU - Schrock, Lauren

AU - Sheth, Sameer

AU - Shih, Ludy

AU - Stanslaski, Scott

AU - Steinke, G. Karl

AU - Stypulkowski, Paul

AU - Troster, Alexander I.

AU - Verhagen, Leo

AU - Walker, Harrison

AU - Okun, Michael S.

N1 - Funding Information: AG: Grant support from Medtronic, Inc.; HK: None; PJR: None; WLA: None; RLA: Consultant for Medtronic, Inc.; HB-S: None; CRB: Consultant for St Jude Medical, Boston Scientific; IP related to DBS; DC: Vanderbilt receives income from grants or contracts from Allergan, Ipsen, Merz and Medtronic for research led by DC; DC receives income from Allergan, Ipsen, Medtronic and, the Alliance for Patient Access for education or consulting services; SD: Employee and shareholder of Sapiens Steering Brain Stimulation GmbH (Medtronic Eindhoven Design Center); CDH: None; MDL: None; DD: Grant support from Medtronic, Cyberonics, Eli Lilly, Roche, Honoraria from Medtronic, Insys, Johnson & Johnson; JE: Chief Medical Officer at Sapiens Steering Brain Stimulation GmbH; KDF: Grant support from Medtronic, St. Jude, Boston Scientific, Neuropace; Consultant for Medtronic, Neuropace; JG: None; WG: None; BDG: None; DG: Employee of Neuropace; RG: None; JJ: None; EK: Employee of St. Jude Medical; AK: Employee of St. Jude Medical; BK: Consultant for Medtronic, St Jude Neuromodulation, MRI Interventions; ALang: Consultant for Abbvie, Allon Therapeutics, Avanir Pharmaceuticals, Biogen Idec, Boerhinger-Ingelheim, Ceregene, Lilly, Medtronic, Merck, Novartis, NeuroPhage Pharmaceuticals, Teva, UCB; Honoraria from Medtronic, Teva, UCB, AbbVie; Grant support from Brain Canada, Canadian Institutes of Health Research, Edmond J Safra Philanthropic Foundation, Michael J. Fox Foundation, the Ontario Brain Institute, National Parkinson Foundation, Parkinson Society Canada, Tourette Syndrome Association, W. Garfield Weston Foundation; Publishing royalties from Saunders, Wiley-Blackwell, Johns Hopkins Press, Cambridge University Press; ALozano: Consultant for Medtronic, St Jude and Boston Scientific, Co-Founder of Functional Neuromodulation; CL: None; KL: Consultant for Medtronic, St. Jude Medical; AM: IP in Enspire, ATI, Cardionomics, Grant support from Medtronic, Inc., Consultant for Functional Neuro-modulation, Spinal Modulation; HM: Employee and shareholder of Sapiens Steering Brain Stimulation GmbH (Medtronic Eindhoven Design Center); CM: IP in Boston Scientific Neuromodulation; Consultant for Boston Scientific Neuromodulation; Shareholder in Autonomic Technologies, Inc., Cardionomics, Inc., Neuros Medical, Inc., Surgical Information Sciences, Inc.; BM: None; HKM: None; JN: Grant support from Medtronic, Inc.; Consultant for Medtronic, Inc., Mon-teris Inc.; JO: Grant support from Boston Scientific, MRI Interventions, St Jude Medical, Medtronic; SP: None; FP: Consultant for Medtronic, Inc; NP: None; DR: Employee of Neuromodulation, Inc; LSchrock: Site PI for the Boston Scientific INTREPID DBS trial; SSheth: None; LShih: None; SStanslanski: Employee of Medtronic, Inc.; GKS: Employee of Boston Scientific Neuromodulation; PS: Employee of Medtronic, Inc.; AT: Consultant for St Jude Medical, Boston Scientific, Theravance, Teva; Grant support from Glaxo Smith Kone, Speaker for Medtronic; Royalties from Oxford University Press; LV: None; HW: None; MSO: Consultant for National Parkinson Foundation; Grant support from NIH, NPF, Michael J. Fox Foundation, Parkinson Alliance, Smallwood Foundation, Bachmann-Strauss Foundation, Tourette Syndrome Association, UF Foundation. Publisher Copyright: © 2015 The Authors.

PY - 2015/7/3

Y1 - 2015/7/3

N2 - The proceedings of the 2nd Annual Deep Brain Stimulation Think Tank summarize the most contemporary clinical, electrophysiological, and computational work on DBS for the treatment of neurological and neuropsychiatric disease and represent the insights of a unique multidisciplinary ensemble of expert neurologists, neurosurgeons, neuropsychologists, psychiatrists, scientists, engineers and members of industry. Presentations and discussions covered a broad range of topics, including advocacy for DBS, improving clinical outcomes, innovations in computational models of DBS, understanding of the neurophysiology of Parkinson's disease (PD) and Tourette syndrome (TS) and evolving sensor and device technologies.

AB - The proceedings of the 2nd Annual Deep Brain Stimulation Think Tank summarize the most contemporary clinical, electrophysiological, and computational work on DBS for the treatment of neurological and neuropsychiatric disease and represent the insights of a unique multidisciplinary ensemble of expert neurologists, neurosurgeons, neuropsychologists, psychiatrists, scientists, engineers and members of industry. Presentations and discussions covered a broad range of topics, including advocacy for DBS, improving clinical outcomes, innovations in computational models of DBS, understanding of the neurophysiology of Parkinson's disease (PD) and Tourette syndrome (TS) and evolving sensor and device technologies.

KW - Deep brain stimulation

KW - Electrophysiology

KW - Movement disorders

KW - Neuroethics

KW - neurotechnology

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DO - 10.3109/00207454.2014.999268

M3 - Review article

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SN - 0020-7454

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Proceedings of the Second Annual Deep Brain Stimulation Think Tank: What's in the Pipeline

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