Proceedings of the Ninth Annual Deep Brain Stimulation Think Tank: Advances in Cutting Edge Technologies, Artificial Intelligence, Neuromodulation, Neuroethics, Pain, Interventional Psychiatry, Epilepsy, and Traumatic Brain Injury

Joshua K. Wong, Günther Deuschl, Robin Wolke, Hagai Bergman, Muthuraman Muthuraman, Sergiu Groppa, Sameer A. Sheth, Helen M. Bronte-Stewart, Kevin B. Wilkins, Matthew N. Petrucci, Emilia Lambert, Yasmine Kehnemouyi, Philip A. Starr, Simon Little, Juan Anso, Ro’ee Gilron, Lawrence Poree, Giridhar P. Kalamangalam, Gregory A. Worrell, Kai J. MillerNicholas D. Schiff, Christopher R. Butson, Jaimie M. Henderson, Jack W. Judy, Adolfo Ramirez-Zamora, Kelly D. Foote, Peter A. Silburn, Luming Li, Genko Oyama, Hikaru Kamo, Satoko Sekimoto, Nobutaka Hattori, James J. Giordano, Diane DiEuliis, John R. Shook, Darin D. Doughtery, Alik S. Widge, Helen S. Mayberg, Jungho Cha, Kisueng Choi, Stephen Heisig, Mosadolu Obatusin, Enrico Opri, Scott B. Kaufman, Prasad Shirvalkar, Christopher J. Rozell, Sankaraleengam Alagapan, Robert S. Raike, Hemant Bokil, David Green, Michael S. Okun

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

DBS Think Tank IX was held on August 25–27, 2021 in Orlando FL with US based participants largely in person and overseas participants joining by video conferencing technology. The DBS Think Tank was founded in 2012 and provides an open platform where clinicians, engineers and researchers (from industry and academia) can freely discuss current and emerging deep brain stimulation (DBS) technologies as well as the logistical and ethical issues facing the field. The consensus among the DBS Think Tank IX speakers was that DBS expanded in its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry. After collectively sharing our experiences, it was estimated that globally more than 230,000 DBS devices have been implanted for neurological and neuropsychiatric disorders. As such, this year’s meeting was focused on advances in the following areas: neuromodulation in Europe, Asia and Australia; cutting-edge technologies, neuroethics, interventional psychiatry, adaptive DBS, neuromodulation for pain, network neuromodulation for epilepsy and neuromodulation for traumatic brain injury.

Original languageEnglish (US)
Article number813387
JournalFrontiers in Human Neuroscience
Volume16
DOIs
StatePublished - Mar 4 2022

Bibliographical note

Funding Information:
JW’s research was supported by NIH R25NS108939. SAS was a consultant for Boston Scientific, Abbott, Zimmer Biomet, and Neuropace. SAS was also funded by NIH UH3 NS103549, the McNair Foundation, and the Dana Foundation. HB-S served on the Clinical Advisory Board for Medtronic. PAS received research support and fellowship training support from Medtronic. NS was a member of the scientific advisory board for EnspireDBS, Inc. and QuantalX, Inc. NS also received current grant funding from the BRAIN Initiative, National Institute of Neurological Disorders and Stroke, and the James S. McDonnell Foundation. CB holds intellectual property related to some of the results presented. CB has served as a consultant for NeuroPace, Advanced Bionics, Boston Scientific, IntelectMedical, Abbott (St. Jude Medical), Functional Neuromodulation, NeuraModix. JH served on the advisory board for Enspire DBS, a consultant for Neuralink and received research support from Boston Scientific. JH also received hardware support from Medtronic for the study described in this article. JJ has received research grants from the Michael J. Fox Foundation. DDD received research support and honoraria from Medtronic. HM received grant support from NIH UH3NS103550, 2R01MH102238, and the Hope for Depression Research Foundation, and consulting and licensing fees from Abbott Labs. PSh received research support from Medtronic but not financial support. MSO served as a consultant for the Parkinson’s Foundation, and has received research grants from NIH, Parkinson’s Foundation, the Michael J. Fox Foundation, the Parkinson Alliance, Smallwood Foundation, the Bachmann-Strauss Foundation, the Tourette Syndrome Association, and the UF Foundation. MSO’s DBS research was supported by: NIH R01 NR014852 and R01NS096008. MSO was PI of the NIH R25NS108939 Training Grant.

Funding Information:
Traumatic Brain Injury (TBI) is a leading cause of long-term disability, due in large part to a lack of effective treatment options. Successful treatment of impaired mental processing speed and executive function could improve patient quality of life. Converging evidence from prior work in rodents, non-human primates and humans has provided evidence to support improving arousal and cognition through stimulation of central thalamus. We initiated a 6-participant feasibility study (CENTURY-S, NCT02881151, funded by NIH BRAIN Initiative grant UH3 NS095554) of central thalamic DBS (CT-DBS) in patients with moderate to severe TBI (msTBI). The trial was based on the hypothesis that activation of down-regulated frontostriatal systems would improve cognitive dysfunction, increase information processing speed and decrease fatiguability. We have reported our preliminary findings on CT-DBS in five participants to date with longstanding functional disability related to persistent cognitive dysfunction after severe TBI (age 23–60, 3–18 years after injury).

Publisher Copyright:
Copyright © 2022 Wong, Deuschl, Wolke, Bergman, Muthuraman, Groppa, Sheth, Bronte-Stewart, Wilkins, Petrucci, Lambert, Kehnemouyi, Starr, Little, Anso, Gilron, Poree, Kalamangalam, Worrell, Miller, Schiff, Butson, Henderson, Judy, Ramirez-Zamora, Foote, Silburn, Li, Oyama, Kamo, Sekimoto, Hattori, Giordano, DiEuliis, Shook, Doughtery, Widge, Mayberg, Cha, Choi, Heisig, Obatusin, Opri, Kaufman, Shirvalkar, Rozell, Alagapan, Raike, Bokil, Green and Okun.

Keywords

  • adaptive DBS
  • artificial intelligence
  • deep brain stimulation
  • epilepsy
  • interventional psychiatry
  • neuroethics
  • pain
  • traumatic brain injury

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