Probiotic use in pediatric kidney transplant recipients: What are current practices, and are they evidence-based? A pediatric nephrology research consortium study

S. J. Kizilbash, H. Connolly, S. Bartosh, R. Zahr, S. Al-Akash, A. Chishti, A. Mansuri, H. Tawadrous, N. G. Jain

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Probiotics are living microorganisms that may confer health benefits to their host if administered in sufficient quantities. However, data on the use of probiotics in transplant recipients are scarce. Method: This multi-center survey of pediatric nephrologists aimed to examine variations in practice regarding the use of probiotics in pediatric kidney transplant recipients. The survey was conducted via a 10-item questionnaire (developed in Survey Monkey) administered to pediatric nephrologists participating in the Pediatric Nephrology Research Consortium meeting in April 2023. Results: Sixty-four pediatric nephrologists completed the survey. Twenty-seven (42.2%) respondents reported having prescribed probiotics to pediatric kidney transplant recipients. The primary reason for probiotic use was the treatment of antibiotic-associated diarrhea (n = 20), with other reasons including recurrent Clostridium difficile infection (n = 15), general gut health promotion (n = 12), recurrent urinary tract infections (n = 8), and parental request (n = 1). Of those who prescribed probiotics, 48.1% held them during periods of neutropenia and 14.8% during central venous line use. Of the 64 respondents, 20 reported the lack of safety data as a concern for using probiotics in kidney transplant recipients. Conclusion: Pediatric nephrologists are increasingly prescribing probiotics to pediatric kidney transplant recipients; nevertheless, substantial practice variations exist. The paucity of safety data is a significant deterrent to probiotic use in this population.

Original languageEnglish (US)
Article numbere14790
JournalPediatric transplantation
Volume28
Issue number5
DOIs
StatePublished - Aug 2024

Bibliographical note

Publisher Copyright:
© 2024 The Author(s). Pediatric Transplantation published by Wiley Periodicals LLC.

Keywords

  • chronic diarrhea
  • pediatric kidney transplant
  • probiotics
  • recurrent urinary tract infections

PubMed: MeSH publication types

  • Journal Article
  • Multicenter Study

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