Probing biological activities with peptide and peptidomimetic biosensors

Laura J Marholz, Tzu Yi Yang, Laurie L. Parker

Research output: Chapter in Book/Report/Conference proceedingChapter


Peptide and peptidomimetic biosensors can be used in combination with a mass spectrometry-based readout to measure or report highly diverse information from biological systems. For example, these biosensors can help us understand reaction mechanisms, assign enzyme substrates, detect ligand interactions, serve as diagnostic tools, and measure enzymatic activity in vitro and in vivo. This chapter highlights and summarizes major recent contributions in this field and includes a detailed protocol as a working example.

Original languageEnglish (US)
Title of host publicationMass Spectrometry-Based Chemical Proteomics
Number of pages27
ISBN (Electronic)9781118970195
ISBN (Print)9781118969557
StatePublished - Jan 1 2019

Bibliographical note

Publisher Copyright:
© 2019 John Wiley & Sons, Inc.


  • Biological activities
  • Diagnostic applications
  • Enzymatic reactions
  • Ligand interactions
  • Peptide biosensors
  • Peptide nucleic acids probe
  • Peptidomimetic biosensors
  • Rapid fire mass-spectrometry
  • Screening inhibitors
  • Substrate specificity


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