Proapoptotic and anticarcinogenic activities of leviusculoside G from the starfish Henricia leviuscula and probable molecular mechanism

Sergey N. Fedorov, Larisa K. Shubina, Alla A. Kicha, Natalia V. Ivanchina, Jong Y. Kwak, Jun O. Jin, Ann M. Bode, Zigang Dong, Valentin A. Stonik

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Proapoptotic and anticarcinogenic properties of leviusculoside G (LSG) isolated from the starfish Henricia leviuscula and a probable mechanism of these effects were investigated in human leukemia HL-60, THP-1, and mouse skin JB6 Cl41 cells, using a variety of assessments, including a cell viability (MTS) assay, flow cytometry, anchorage-independent soft agar assay, luciferase assay, and western-blotting. Application of LSG at nontoxic doses induced apoptosis in cancer cells and decreased cell transformation. This compound exerted its actions, at least in part, through the induction of p53-dependent apoptosis and inhibition of AP-1, NF-κB, and ERKs activities.

Original languageEnglish (US)
Pages (from-to)1575-1580
Number of pages6
JournalNatural Product Communications
Volume3
Issue number10
DOIs
StatePublished - 2008

Keywords

  • AP-1 and p53 nuclear factors
  • Apoptosis of cancer cells
  • Cancer preventive activity
  • Starfish
  • Steroidal glycoside

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