Pro- and anti-inflammatory cytokine expression and histopathological characteristics in canine brain with traumatic brain injury

Chi Ho Yu, Ji Young Yhee, Jong Hyuk Kim, Keum Soon Im, Na Hyun Kim, Dong In Jung, Hee Chun Lee, Seung Ki Chon, Jung Hyang Sur

Research output: Contribution to journalArticle

20 Scopus citations


We analyzed the expression level and cellular localization of pro- and anti-inflammatory cytokines and histopathologically characterized canine traumatic brain injury (TBI). Canine TBI brains revealed subarachnoid and cerebral cortical hemorrhage, neutrophilic infiltration, neuronal necrosis, astrocytosis, and vasogenic edema. Immunohistochemical evaluations suggested that both pro-inflammatory cytokines [interleukin (IL)-1β, IL-6, and tumor necrosis factor-α] and anti-inflammatory cytokines [IL-10 and transforming growth factor-beta (TGF-β)] were highly expressed in neurons and neutrophils. In particular, the highest magnitude of expression was identified for IL-1β and TGF-β. This data helps describe the pathologic characteristics of canine TBI, and may help in the design of potential therapeutic approaches to control secondary damage by inflammatory cytokines.

Original languageEnglish (US)
Pages (from-to)299-301
Number of pages3
JournalJournal of veterinary science
Issue number3
StatePublished - Aug 31 2011



  • Interleukin-1
  • Interleukin-6
  • Transforming growth factor-beta
  • Traumatic brain injury
  • Tumor necrosis factor-alpha

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