Prion forensics: a multidisciplinary approach to investigate CWD at an illegal deer carcass disposal site

Marc D. Schwabenlander; Jason C. Bartz; Michelle Carstensen; Alberto Fameli; Linda Glaser; Roxanne J. Larsen; Manci Li; Rachel L. Shoemaker; Gage Rowden; Suzanne Stone; W. David Walter; Tiffany M. Wolf; Peter A. Larsen

doi:10.1080/19336896.2024.2343298

Prion forensics: a multidisciplinary approach to investigate CWD at an illegal deer carcass disposal site

Marc D. Schwabenlander, Jason C. Bartz, Michelle Carstensen, Alberto Fameli, Linda Glaser, Roxanne J. Larsen, Manci Li, Rachel L. Shoemaker, Gage Rowden, Suzanne Stone, W. David Walter, Tiffany M. Wolf, Peter A. Larsen

Research output: Contribution to journal › Article › peer-review

Abstract

Infectious prions are resistant to degradation and remain infectious in the environment for several years. Chronic wasting disease (CWD) has been detected in cervids inhabiting North America, the Nordic countries, and South Korea. CWD-prion spread is partially attributed to carcass transport and disposal. We employed a forensic approach to investigate an illegal carcass dump site connected with a CWD-positive herd. We integrated anatomic, genetic, and prion amplification methods to discover CWD-positive remains from six white-tailed deer (Odocoileus virginianus) and, using microsatellite markers, confirmed a portion originated from the CWD-infected herd. This approach provides a foundation for future studies of carcass prion transmission risk.

Original language	English (US)
Pages (from-to)	72-86
Number of pages	15
Journal	Prion
Volume	18
Issue number	1
DOIs	https://doi.org/10.1080/19336896.2024.2343298
State	Published - 2024

Bibliographical note

Publisher Copyright:
© 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

Keywords

Cervid
chronic wasting disease
ecology
environment
genetics
transmission

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/19336896.2024.2343298

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title = "Prion forensics: a multidisciplinary approach to investigate CWD at an illegal deer carcass disposal site",

abstract = "Infectious prions are resistant to degradation and remain infectious in the environment for several years. Chronic wasting disease (CWD) has been detected in cervids inhabiting North America, the Nordic countries, and South Korea. CWD-prion spread is partially attributed to carcass transport and disposal. We employed a forensic approach to investigate an illegal carcass dump site connected with a CWD-positive herd. We integrated anatomic, genetic, and prion amplification methods to discover CWD-positive remains from six white-tailed deer (Odocoileus virginianus) and, using microsatellite markers, confirmed a portion originated from the CWD-infected herd. This approach provides a foundation for future studies of carcass prion transmission risk.",

keywords = "Cervid, chronic wasting disease, ecology, environment, genetics, transmission",

author = "Schwabenlander, {Marc D.} and Bartz, {Jason C.} and Michelle Carstensen and Alberto Fameli and Linda Glaser and Larsen, {Roxanne J.} and Manci Li and Shoemaker, {Rachel L.} and Gage Rowden and Suzanne Stone and Walter, {W. David} and Wolf, {Tiffany M.} and Larsen, {Peter A.}",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.",

year = "2024",

doi = "10.1080/19336896.2024.2343298",

language = "English (US)",

volume = "18",

pages = "72--86",

journal = "Prion",

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T1 - Prion forensics

T2 - a multidisciplinary approach to investigate CWD at an illegal deer carcass disposal site

AU - Schwabenlander, Marc D.

AU - Bartz, Jason C.

AU - Carstensen, Michelle

AU - Fameli, Alberto

AU - Glaser, Linda

AU - Larsen, Roxanne J.

AU - Li, Manci

AU - Shoemaker, Rachel L.

AU - Rowden, Gage

AU - Stone, Suzanne

AU - Walter, W. David

AU - Wolf, Tiffany M.

AU - Larsen, Peter A.

PY - 2024

Y1 - 2024

N2 - Infectious prions are resistant to degradation and remain infectious in the environment for several years. Chronic wasting disease (CWD) has been detected in cervids inhabiting North America, the Nordic countries, and South Korea. CWD-prion spread is partially attributed to carcass transport and disposal. We employed a forensic approach to investigate an illegal carcass dump site connected with a CWD-positive herd. We integrated anatomic, genetic, and prion amplification methods to discover CWD-positive remains from six white-tailed deer (Odocoileus virginianus) and, using microsatellite markers, confirmed a portion originated from the CWD-infected herd. This approach provides a foundation for future studies of carcass prion transmission risk.

AB - Infectious prions are resistant to degradation and remain infectious in the environment for several years. Chronic wasting disease (CWD) has been detected in cervids inhabiting North America, the Nordic countries, and South Korea. CWD-prion spread is partially attributed to carcass transport and disposal. We employed a forensic approach to investigate an illegal carcass dump site connected with a CWD-positive herd. We integrated anatomic, genetic, and prion amplification methods to discover CWD-positive remains from six white-tailed deer (Odocoileus virginianus) and, using microsatellite markers, confirmed a portion originated from the CWD-infected herd. This approach provides a foundation for future studies of carcass prion transmission risk.

KW - Cervid

KW - chronic wasting disease

KW - ecology

KW - environment

KW - genetics

KW - transmission

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DO - 10.1080/19336896.2024.2343298

M3 - Article

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AN - SCOPUS:85191638089

SN - 1933-6896

VL - 18

SP - 72

EP - 86

JO - Prion

JF - Prion

IS - 1

ER -

Prion forensics: a multidisciplinary approach to investigate CWD at an illegal deer carcass disposal site

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

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