Principles of unconventional myosin function and targeting

M. Amanda Hartman, Dina Finan, Sivaraj Sivaramakrishnan, James A. Spudich

Research output: Contribution to journalArticlepeer-review

130 Scopus citations


Unconventional myosins are a superfamily of actin-based motors implicated in diverse cellular processes. In recent years, much progress has been made in describing their biophysical properties, and headway has been made into analyzing their cellular functions. Here, we focus on the principles that guide in vivo motor function and targeting to specific cellular locations. Rather than describe each motor comprehensively, we outline the major themes that emerge from research across the superfamily and use specific examples to illustrate each. In presenting the data in this format, we seek to identify open questions in each field as well as to point out commonalities between them. To advance our understanding of myosins' roles in vivo, clearly we must identify their cellular cargoes and the protein complexes that regulate motor attachment to fully appreciate their functions on the cellular and developmental levels.

Original languageEnglish (US)
Pages (from-to)133-155
Number of pages23
JournalAnnual Review of Cell and Developmental Biology
StatePublished - 2011


  • Actin
  • Cargo
  • Cytoskeleton
  • Motor protein
  • Trafficking


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