Principles of Transfusion Support Before and After Hematopoietic Cell Transplantation

Jeffrey Mc Cullough

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Patients who are candidates for or are undergoing hematopoietic cell transplantation (HCT) have unique transfusion requirements. These are due to the need to minimize the likelihood of alloimmunization. An effective blood bank and transfusion medicine program are essential for a successful HCT program. This chapter talks focuses on red blood cells (RBCs), leukocyte-reduced red cells, washed red cells, and coagulation factor components, namely fresh frozen plasma (FFP) and cryoprecipitate and fibrinogen. Blood group compatibility of components used to replace coagulation factors and platelet components, and transfusion therapy for HCT donors, are also discussed. Transfusion-transmitted diseases include acquired immune deficiency syndrome (AIDS), hepatitis B virus (HBV), syphilis, human T-lymphotrophic virus-I (HTLV-I), and Epstein-Barr virus (EBV). Following transplantation, patient transfusion needs can be met effectively. The blood supply is safer than ever, and although some risks of infection remain, most patients can be supported safely and effectively.

Original languageEnglish (US)
Title of host publicationThomas' Hematopoietic Cell Transplantation
Subtitle of host publicationFifth Edition
PublisherWiley Blackwell
Pages961-979
Number of pages19
Volume2-2
ISBN (Electronic)9781118416426
ISBN (Print)9781118416006
DOIs
StatePublished - Jan 1 2016

Keywords

  • Blood transfusion
  • Coagulation factors
  • Fresh frozen plasma
  • Hematopoietic cell transplantation
  • Platelet components
  • Red blood cells
  • Transfusion support
  • Transfusion-transmitted diseases

Fingerprint Dive into the research topics of 'Principles of Transfusion Support Before and After Hematopoietic Cell Transplantation'. Together they form a unique fingerprint.

  • Cite this

    Mc Cullough, J. (2016). Principles of Transfusion Support Before and After Hematopoietic Cell Transplantation. In Thomas' Hematopoietic Cell Transplantation: Fifth Edition (Vol. 2-2, pp. 961-979). Wiley Blackwell. https://doi.org/10.1002/9781118416426.ch79