Principles of cryopreservation

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations


Biospecimens are important reagents that are used to diagnose disease, monitor response to treatment and help in the development and testing of new therapies to treat human disease. In order to provide these critical functions, biospecimens need to maintain their requisite biological properties between the time that they are collected and when they are used. It is common for biospecimens to be frozen to preserve those critical biological properties. The purpose of this chapter is to describe our scientific understanding behind the freezing, storage and thawing processes that take place during cryopreservation and the manner by which these processes can preserve or damage the sample. Practical hints for applying scientific principles to daily biobanking practice are also included.

Original languageEnglish (US)
Title of host publicationBiobanking of Human Biospecimens
Subtitle of host publicationPrinciples and Practice
PublisherSpringer International Publishing
Number of pages21
ISBN (Electronic)9783319551203
ISBN (Print)9783319551180
StatePublished - Jul 6 2017

Bibliographical note

Publisher Copyright:
© Springer International Publishing AG 2017. All rights reserved.


  • Biospecimens
  • Cooling rate
  • Cryopreservation
  • Storage temperature
  • Warming rate


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