Principles of computer numerical control applied to small research animal surgical procedures

Mathew Rynes, Leila Ghanbari, Jay Jia Hu, Daniel Sousa Schulman, Gregory Johnson, Michael Laroque, Suhasa Bangalore Kodandaramaiah

Research output: Contribution to conferencePaper

Abstract

The tools and techniques available for systems neuroscientists for neural recording and stimulation during behavior have become plentiful in the last decade. The tools for implementing these techniques in vivo, however, have not advanced respectively. The use of these techniques requires the removal of sections of skull tissue without damaging the underlying tissue, which is a very delicate procedure requiring significant training. Automating a part of the tissue removal processes would potentially enable more precise procedures to be performed, and it could democratize these procedres for widespread adoption by neuroscience lab groups. Here, we describe the ‘Craniobot’, a microsurgery platform that combines automated skull surface profiling with a computer numerical controlled (CNC) milling machine to perform a variety of microsurgical procedures in mice. Surface profiling by the Craniobot has micrometer precision, and the surface profiling information can be used to perform milling operations with relatively quick, allowing high throughput. We have used the Craniobot to perform skull thinning, small to large craniotomies, as well as drilling pilot holes for anchoring cranial implants. The Craniobot is implemented using open source and customizable machining practices and can be built with of the shelf parts for under $1000.

Original languageEnglish (US)
DOIs
StatePublished - Jan 1 2018
Event2018 Design of Medical Devices Conference, DMD 2018 - Minneapolis, United States
Duration: Apr 9 2018Apr 12 2018

Other

Other2018 Design of Medical Devices Conference, DMD 2018
CountryUnited States
CityMinneapolis
Period4/9/184/12/18

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Animals
Tissue
Milling machines
Drilling
Machining
Throughput

Cite this

Rynes, M., Ghanbari, L., Hu, J. J., Schulman, D. S., Johnson, G., Laroque, M., & Bangalore Kodandaramaiah, S. (2018). Principles of computer numerical control applied to small research animal surgical procedures. Paper presented at 2018 Design of Medical Devices Conference, DMD 2018, Minneapolis, United States. https://doi.org/10.1115/DMD2018-6959

Principles of computer numerical control applied to small research animal surgical procedures. / Rynes, Mathew; Ghanbari, Leila; Hu, Jay Jia; Schulman, Daniel Sousa; Johnson, Gregory; Laroque, Michael; Bangalore Kodandaramaiah, Suhasa.

2018. Paper presented at 2018 Design of Medical Devices Conference, DMD 2018, Minneapolis, United States.

Research output: Contribution to conferencePaper

Rynes, M, Ghanbari, L, Hu, JJ, Schulman, DS, Johnson, G, Laroque, M & Bangalore Kodandaramaiah, S 2018, 'Principles of computer numerical control applied to small research animal surgical procedures' Paper presented at 2018 Design of Medical Devices Conference, DMD 2018, Minneapolis, United States, 4/9/18 - 4/12/18, . https://doi.org/10.1115/DMD2018-6959
Rynes M, Ghanbari L, Hu JJ, Schulman DS, Johnson G, Laroque M et al. Principles of computer numerical control applied to small research animal surgical procedures. 2018. Paper presented at 2018 Design of Medical Devices Conference, DMD 2018, Minneapolis, United States. https://doi.org/10.1115/DMD2018-6959
Rynes, Mathew ; Ghanbari, Leila ; Hu, Jay Jia ; Schulman, Daniel Sousa ; Johnson, Gregory ; Laroque, Michael ; Bangalore Kodandaramaiah, Suhasa. / Principles of computer numerical control applied to small research animal surgical procedures. Paper presented at 2018 Design of Medical Devices Conference, DMD 2018, Minneapolis, United States.
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