Primers on molecular pathways - Ion channels: Key regulators of pancreatic physiology

Jesús M. Banales, Sergio A. Gradilone

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Ion transport across the cellular plasma membrane is important in almost every physiological process. This phenomenon is driven by the coordinated action of carriers, pumps and channels, which move ions in and out the cells and between different organelles. Ion channels are transmembrane proteins that provide a continuous aqueous pore through which ions can selectively move. The interest in these molecules has increased due to the recognition of diverse pathologies related with mutations in genes encoding these transmembrane proteins, now known as channelopathies. Ion channels play a variety of functions in the pancreas. Here, we briefly describe ion transport characteristics as well as their role in pancreas physiology and pathophysiology.

Original languageEnglish (US)
Pages (from-to)556-559
Number of pages4
JournalPancreatology
Volume9
Issue number5
DOIs
StatePublished - Nov 2009
Externally publishedYes

Keywords

  • Ion channels
  • Key regulators of pancreatic physiology
  • Primers on molecular pathways

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