Primary Infection with Zidovudine-Resistant Human Immunodeficiency Virus Type 1

Alejo Erice; Douglas L. Mayers; David G. Strike; Kim J. Sannerud; Francine E. McCutchan; Keith Henry; Henry H. Balfour

doi:10.1056/NEJM199304223281605

Primary Infection with Zidovudine-Resistant Human Immunodeficiency Virus Type 1

Alejo Erice, Douglas L. Mayers, David G. Strike, Kim J. Sannerud, Francine E. McCutchan, Keith Henry, Henry H. Balfour

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225 Scopus citations

Abstract

Strains of human immunodeficiency virus type 1 (HIV-1) with reduced sensitivity to zidovudine have been isolated from patients treated with this drug for six months or more¹. Resistance to zidovudine is associated with late-stage disease, low CD4 lymphocyte counts, longer antiretroviral therapy, and specific mutations in the reverse transcriptase gene of HIV-1²,³. The clinical importance of infections with resistant HIV-1 isolates is not well understood. We describe a patient with symptomatic HIV-1 infection who had primary infection with a virus resistant to zidovudine, according to both phenotypic and genotypic analyses. Case Report The patient was a 20-year-old…

Original language	English (US)
Pages (from-to)	1163-1165
Number of pages	3
Journal	New England Journal of Medicine
Volume	328
Issue number	16
DOIs	https://doi.org/10.1056/NEJM199304223281605
State	Published - Apr 22 1993

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abstract = "Strains of human immunodeficiency virus type 1 (HIV-1) with reduced sensitivity to zidovudine have been isolated from patients treated with this drug for six months or more1. Resistance to zidovudine is associated with late-stage disease, low CD4 lymphocyte counts, longer antiretroviral therapy, and specific mutations in the reverse transcriptase gene of HIV-12,3. The clinical importance of infections with resistant HIV-1 isolates is not well understood. We describe a patient with symptomatic HIV-1 infection who had primary infection with a virus resistant to zidovudine, according to both phenotypic and genotypic analyses. Case Report The patient was a 20-year-old…",

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T1 - Primary Infection with Zidovudine-Resistant Human Immunodeficiency Virus Type 1

AU - Erice, Alejo

AU - Mayers, Douglas L.

AU - Strike, David G.

AU - Sannerud, Kim J.

AU - McCutchan, Francine E.

AU - Henry, Keith

AU - Balfour, Henry H.

PY - 1993/4/22

Y1 - 1993/4/22

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AB - Strains of human immunodeficiency virus type 1 (HIV-1) with reduced sensitivity to zidovudine have been isolated from patients treated with this drug for six months or more1. Resistance to zidovudine is associated with late-stage disease, low CD4 lymphocyte counts, longer antiretroviral therapy, and specific mutations in the reverse transcriptase gene of HIV-12,3. The clinical importance of infections with resistant HIV-1 isolates is not well understood. We describe a patient with symptomatic HIV-1 infection who had primary infection with a virus resistant to zidovudine, according to both phenotypic and genotypic analyses. Case Report The patient was a 20-year-old…

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Primary Infection with Zidovudine-Resistant Human Immunodeficiency Virus Type 1

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