Primary Infection with Zidovudine-Resistant Human Immunodeficiency Virus Type 1

Alejo Erice, Douglas L. Mayers, David G. Strike, Kim J. Sannerud, Francine E. McCutchan, Keith Henry, Henry H. Balfour

Research output: Contribution to journalArticlepeer-review

214 Scopus citations


Strains of human immunodeficiency virus type 1 (HIV-1) with reduced sensitivity to zidovudine have been isolated from patients treated with this drug for six months or more1. Resistance to zidovudine is associated with late-stage disease, low CD4 lymphocyte counts, longer antiretroviral therapy, and specific mutations in the reverse transcriptase gene of HIV-12,3. The clinical importance of infections with resistant HIV-1 isolates is not well understood. We describe a patient with symptomatic HIV-1 infection who had primary infection with a virus resistant to zidovudine, according to both phenotypic and genotypic analyses. Case Report The patient was a 20-year-old…

Original languageEnglish (US)
Pages (from-to)1163-1165
Number of pages3
JournalNew England Journal of Medicine
Issue number16
StatePublished - Apr 22 1993


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