Abstract
Strains of human immunodeficiency virus type 1 (HIV-1) with reduced sensitivity to zidovudine have been isolated from patients treated with this drug for six months or more1. Resistance to zidovudine is associated with late-stage disease, low CD4 lymphocyte counts, longer antiretroviral therapy, and specific mutations in the reverse transcriptase gene of HIV-12,3. The clinical importance of infections with resistant HIV-1 isolates is not well understood. We describe a patient with symptomatic HIV-1 infection who had primary infection with a virus resistant to zidovudine, according to both phenotypic and genotypic analyses. Case Report The patient was a 20-year-old…
Original language | English (US) |
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Pages (from-to) | 1163-1165 |
Number of pages | 3 |
Journal | New England Journal of Medicine |
Volume | 328 |
Issue number | 16 |
DOIs | |
State | Published - Apr 22 1993 |