Primary Infection with Zidovudine-Resistant HIV

P. Hermans, S. Sprecher, N. Clumeck, Bernard Masquelier, Emmanuelle Lemoigne, Isabelle Pellegrin, Danielle Douard, Boris Sandler, Herve J.a. Fleury, Alejo Erice, Henry H. Balfour

Research output: Contribution to journalLetterpeer-review

23 Scopus citations


To the Editor: Erice et al. (April 22 issue)1 described a patient with symptomatic human immunodeficiency virus type 1 (HIV-1) infection who had a primary infection with a virus resistant to zidovudine. We report the case of a homosexual man in whom clinical symptoms of acute HIV-1 infection developed in May 1992; tests for HIV-1 antibodies were positive in July 1992. His most recent negative HIV-1 test was in November 1991. We studied the presence of genotypic mutations at codons 215 and 74 of the HIV pol gene – those associated with reduced sensitivity to zidovudine and didanosine, respectively. We…

Original languageEnglish (US)
Pages (from-to)1123-1124
Number of pages2
JournalNew England Journal of Medicine
Issue number15
StatePublished - Oct 7 1993


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