Abstract
Cilia are microtubule-based organelles, which are ubiquitously expressed in epithelial cells. Cholangiocytes, the epithelial cells lining the biliary tree, have primary cilia extending from their apical plasma membrane into the ductal lumen, where the cilia function as multisensory organelles transducing environmental cues into the cell interior. The decrease or loss of primary cilia has been described in several malignancies, including cholangiocarcinoma, suggesting that the loss of cilia is a common occurrence in neoplastic transformation. In this short review, we describe the expression of cilia in several cancers, explore the mechanisms and consequences of ciliary loss, and discuss the potential use of the primary cilia as therapeutic targets.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 958-963 |
| Number of pages | 6 |
| Journal | Current Drug Targets |
| Volume | 18 |
| Issue number | 8 |
| DOIs | |
| State | Published - Jan 1 2017 |
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Keywords
- Bile duct cancer
- Cholangiocarcinoma
- Cholangiocyte
- Ciliotherapy
- HDAC6
- Primary cilia
Cite this
Primary cilia in tumor biology : The primary cilium as a therapeutic target in cholangiocarcinoma. / Gradilone, Sergio; Lorenzo Pisarello, María J.; LaRusso, Nicholas F.
In: Current Drug Targets, Vol. 18, No. 8, 01.01.2017, p. 958-963.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Primary cilia in tumor biology
T2 - The primary cilium as a therapeutic target in cholangiocarcinoma
AU - Gradilone, Sergio
AU - Lorenzo Pisarello, María J.
AU - LaRusso, Nicholas F.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Cilia are microtubule-based organelles, which are ubiquitously expressed in epithelial cells. Cholangiocytes, the epithelial cells lining the biliary tree, have primary cilia extending from their apical plasma membrane into the ductal lumen, where the cilia function as multisensory organelles transducing environmental cues into the cell interior. The decrease or loss of primary cilia has been described in several malignancies, including cholangiocarcinoma, suggesting that the loss of cilia is a common occurrence in neoplastic transformation. In this short review, we describe the expression of cilia in several cancers, explore the mechanisms and consequences of ciliary loss, and discuss the potential use of the primary cilia as therapeutic targets.
AB - Cilia are microtubule-based organelles, which are ubiquitously expressed in epithelial cells. Cholangiocytes, the epithelial cells lining the biliary tree, have primary cilia extending from their apical plasma membrane into the ductal lumen, where the cilia function as multisensory organelles transducing environmental cues into the cell interior. The decrease or loss of primary cilia has been described in several malignancies, including cholangiocarcinoma, suggesting that the loss of cilia is a common occurrence in neoplastic transformation. In this short review, we describe the expression of cilia in several cancers, explore the mechanisms and consequences of ciliary loss, and discuss the potential use of the primary cilia as therapeutic targets.
KW - Bile duct cancer
KW - Cholangiocarcinoma
KW - Cholangiocyte
KW - Ciliotherapy
KW - HDAC6
KW - Primary cilia
UR - http://www.scopus.com/inward/record.url?scp=85020419365&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85020419365&partnerID=8YFLogxK
U2 - 10.2174/1389450116666150223162737
DO - 10.2174/1389450116666150223162737
M3 - Review article
VL - 18
SP - 958
EP - 963
JO - Current Drug Targets
JF - Current Drug Targets
SN - 1389-4501
IS - 8
ER -