Primary bilateral corneal nerve sheath neoplasm in a dog

Marina L. Leis, M. Elyse Salpeter, Bianca S. Bauer, Dale L. Godson, Bruce H. Grahn

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


A 15-year-old, neutered male, Shih Tzu cross developed progressive corneal stromal thickening and vascularization of the right eye, and 5 months later, of the left eye. Both eyes became blind due to extensive corneal opacification and were enucleated. Light microscopic examination revealed a diffuse corneal infiltrate of neoplastic mesenchymal cells, and immunohistochemistry revealed diffuse cytoplasmic vimentin immunoreactivity and variable cytoplasmic and nuclear immunoreactivity for S100 in the neoplastic cells. Transmission electron microscopy revealed desmosomes between contiguous cells, thread-like cytoplasmic processes coated with basement membrane, extracellular bundles of collagen, and axonal degeneration consistent with features of a nerve sheath neoplasm. This is the first report of primary, bilateral corneal nerve sheath sarcoma in a canine.

Original languageEnglish (US)
Pages (from-to)365-371
Number of pages7
JournalVeterinary Ophthalmology
Issue number4
StatePublished - Jul 2017

Bibliographical note

Publisher Copyright:
© 2016 American College of Veterinary Ophthalmologists


  • canine
  • corneal neoplasia
  • electron microscopy
  • histopathology
  • immunohistochemistry
  • nerve sheath neoplasm


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