Abstract
An enantioselective synthesis of Rauhut-Currier (RC) adducts from 3-aryl cyclohexenone with a tethered enone moiety at the ortho-position on the aryl group is accomplished. This method provides a wide range of valuable synthetic building blocks having a unique [6-5-6] all-carbon-fused tricyclic skeleton. A primary amine-containing thiourea, a bifunctional organocatalyst, was found to be an efficient catalyst for this transformation. The primary amine counterpart of the catalyst possibly activates the aliphatic enone via dienamine formation (HOMO activation), whereas the thiourea counterpart activates the tethered enone (LUMO activation). Considering the difficulty in achieving an RC reaction of β,β-disubstituted (alkyl and aryl) enones, this method would be significantly rewarding.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1707-1711 |
| Number of pages | 5 |
| Journal | Organic Letters |
| Volume | 20 |
| Issue number | 7 |
| DOIs | |
| State | Published - Apr 6 2018 |
| Externally published | Yes |
Bibliographical note
Funding Information:This work has been funded by IISER Bhopal and CSIR, India. S.M. and S.S. thank UGC and CSIR, New Delhi, India, respectively, for fellowships. We thank Mr. Darpan Agarwal (IISER Bhopal) for his help.
Publisher Copyright:
© 2018 American Chemical Society.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.