Guidance to authors is needed to prevent their waste of talent, time and resources in writing manuscripts that will never be published in the highest-quality journals. Laboratory studies are probably the most common type of endodontic research projects because they make up the majority of manuscripts submitted for publication. Unfortunately, most of these manuscripts fail the peer-review process, primarily due to critical flaws in the reporting of the methods and results. Here, in order to guide authors, the Preferred Reporting Items for study Designs in Endodontology (PRIDE) team developed new reporting guidelines for laboratory-based studies: the Preferred Reporting Items for Laboratory studies in Endodontology (PRILE) 2021 guidelines. The PRILE 2021 guidelines were developed exclusively for the area of Endodontology by integrating and adapting the modified CONSORT checklist of items for reporting in vitro studies of dental materials and the Clinical and Laboratory Images in Publications (CLIP) principles. The process of developing the PRILE 2021 guidelines followed the recommendations of the Guidance for Developers of Health Research Reporting Guidelines. The aim of the current document is to provide authors with an explanation for each of the items in the PRILE 2021 checklist and flowchart with examples from the literature, and to provide advice from peer-reviewers and editors about how to solve each problem in manuscripts prior to their peer-review. The Preferred Reporting Items for study Designs in Endodontology (PRIDE) website (http://pride-endodonticguidelines.org/prile/) provides a link to the PRILE 2021 explanation and elaboration document as well as to the checklist and flowchart.
Bibliographical noteFunding Information:
The first author (V Nagendrababu) was associated previously with the School of Dentistry, International Medical University, Kuala Lumpur, Malaysia, where the ethical clearance was obtained (No: IMU 450/2019) and the study was conducted. The first author (V Nagendrababu) is now associated with the University of Sharjah, Sharjah, United Arab Emirates, where further ethical clearance was obtained (REC-20-11-06-01). The authors are most thankful to Professor Michael V?th, Department of Public Health, Aarhus University, Aarhus, Denmark, for his valuable advice and suggestion with the statistical terms. We would like to thank those who helped in sharing their views on the PRILE 2021 Explanation and Elaboration document: Vasudev Ballal, India; Tao Hu, China; Bill Kahler, Australia; Emmanuel Silva, Brazil; Renato M Silva, US; and Victoria Yu, Singapore. The authors gratefully acknowledge the contributors whose work has been reproduced in this publication. The authors deny any responsibility for any potential errors, omissions, or artifacts that may be discovered outside of their control.
From Rathinam et al. ( 2020 ) ‐ “Dr. Govindarajan holds a post‐doctoral fellowship from the Fund for Scientific Research – Flanders (FWO). The research was supported by grants from the Group‐ID Multidisciplinary Platform (MRP) of Ghent University (Dr. Elewaut) and Fund for Scientific Research – Flanders (Dr. Elewaut). Dr. Rajasekahran holds a post‐doctoral fellowship from the Fund for Scientific Research – Flanders (FWO). The authors would like to report research grants and non‐financial support (i.e., cement materials free of charge) from Septodont, France. Outside of the submitted work, Dr. Martens and Dr. Rajasekharan report personal fees (honoraria/lecture fees/educational courses). In addition, Dr. Martens would like to report research grants from Septodont, France, negotiated with the Ghent University. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results”.
From Kishen et al. ( 2018 ) ‐ “Supported by a grant from the University of Toronto (A.K.) (grant no. 928133). The authors thank Ms. Martha Cordova for technical support. The authors deny any conflicts of interest related to this study”.
© 2021 International Endodontic Journal. Published by John Wiley & Sons Ltd
- health research
- in-vitro study
- laboratory study
- reporting guidelines
PubMed: MeSH publication types
- Journal Article