Reproducible, skilfully conducted and unbiased laboratory studies provide new knowledge, which can inform clinical research and eventually translate into better patient care. To help researchers improve the quality and reproducibility of their research prior to a publication peer-review, this paper describes the process that was followed during the development of the Preferred Reporting Items for Laboratory studies in Endodontology (PRILE) 2021 guidelines and which used a well-documented consensus-based methodology. A steering committee was created with eight individuals (PM, RO, OP, IR, JS, EP, JJ and SP), plus the project leaders (PD, VN). The steering committee prepared an initial checklist by combining and adapting items from the modified Consolidated Statement of Reporting Trials checklist for reporting in vitro studies of dental materials and the Clinical and Laboratory Images in Publications principles as well as adding several new items. The steering committee then formed a PRILE Delphi Group (PDG) and PRILE Online Meeting Group (POMG) to provide expert advice and feedback on the initial draft checklist and flowchart. The members of the PDG participated in an online Delphi process to achieve consensus on the items within the PRILE 2021 checklist and the accompanying flowchart for clarity and suitability. The PRILE checklist and flowchart developed by the online Delphi process were discussed further by the POMG. This online meeting was conducted on 12 February 2021 via the Zoom platform. Following this meeting, the steering committee developed a final version of the PRILE 2021 guidelines and flowchart, which was piloted by several authors when writing up a laboratory study for publication. Authors are encouraged to use the PRILE 2021 guidelines and flowchart to improve the clarity, completeness and quality of reports describing laboratory studies in Endodontology. The PRILE 2021 checklist and flowchart are freely available and downloadable from the Preferred Reporting Items for study Designs in Endodontology website (http://pride-endodonticguidelines.org/prile/).
Bibliographical noteFunding Information:
The first author (V Nagendrababu) was associated previously with the School of Dentistry, International Medical University, Kuala Lumpur, Malaysia, where the ethical clearance was obtained (No: IMU 450/2019) and where the study was conducted. The first author (V Nagendrababu) is now associated with the University of Sharjah, Sharjah, United Arab Emirates, where a further ethical clearance was obtained (REC-20-11-06-01). The project leaders (PD, VN) would like to thank the Tehran University of Medical Sciences (TUMS), Tehran, Iran, for managing the Zoom platform during the online meeting. The authors are most thankful to Professor Michael V?th, Department of Public Health, Aarhus University, Aarhus, Denmark, for his valuable advice and suggestion with the statistical terms. The authors also thank the individuals who participated in the online Delphi process and online meeting: Hany Mohamed Aly Ahmed, Malaysia; Fl?vio Alves, Brazil; Ana Arias, Spain; Harikrishna Babhu, India; Vasudev Ballal, India; Shekhar Bhatia, Malaysia; Mohan Bhuvaneswaran, India; Sebastian B?rklein, Germany; Luis Chavez de Paz, Sweden; Marco Antonio Hungaro Duarte, Brazil; Ben Dummer, UK; Nicholas Dummer, UK; Hal Duncan, Ireland; Ashraf Fouad, USA; Kerstin Galler, Germany; Tao Hu, China; Bill Kahler, Australia; Anil Kishen, Canada; Jorge NR Martins, Portugal; Jayaraman Nagaiyah, India; Mohammad Nekoofar, Iran; Peter Parashos, Australia; Christine Peters, Australia; Maria Pigg, Sweden; Gianluca Plotino, Italy; Edgar Sch?fer, Germany; Mahalaxmi Sekar, India; Frank Setzer, USA; Annie Shrestha, Canada; Emmanuel Silva, Brazil; Renato M Silva, US; Manoel D. Sousa-Neto, Brazil; Erick Souza, Brazil; Vinothkumar Thilla Sekar, Saudi Arabia; Pia Titterude, Norway; Phillip Tomson, UK; Igor Tsesis, Israel; Victoria Yu, Singapore.
© 2021 International Endodontic Journal. Published by John Wiley & Sons Ltd
- laboratory study