Virulent (wild) murine cyto-megalovirus results in morbidity, weight loss, immunosuppression, and death in infected mice. An attenuated, tissue culture-passaged strain of CMV protected mice from the morbid, immunosuppressive, and lethal effects of subsequent challenge with virulent virus. In addition, vaccination with attenuated CMV led to an enhanced humoral antibody response to SRBC and decreased mean skin graft survival time.
|Original language||English (US)|
|Number of pages||4|
|Journal||Proceedings of the Society for Experimental Biology and Medicine|
|State||Published - Nov 1977|
Bibliographical noteFunding Information:
Supported in part by USPHS Grants HLO6314 and AM18883. 2