Prevention of Morbidity and Mortality of Wild Murine Cytomegalovirus by Vaccination with Attenuated Cytomegalovirus

R. J. Howard, Henry H Balfour

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Virulent (wild) murine cyto-megalovirus results in morbidity, weight loss, immunosuppression, and death in infected mice. An attenuated, tissue culture-passaged strain of CMV protected mice from the morbid, immunosuppressive, and lethal effects of subsequent challenge with virulent virus. In addition, vaccination with attenuated CMV led to an enhanced humoral antibody response to SRBC and decreased mean skin graft survival time.

Original languageEnglish (US)
Pages (from-to)365-368
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume156
Issue number2
DOIs
StatePublished - Nov 1977

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