Prevention and early detection of prostate cancer

Jack Cuzick, Mangesh A. Thorat, Gerald Andriole, Otis W. Brawley, Powel H. Brown, Zoran Culig, Rosalind A. Eeles, Leslie G. Ford, Freddie C. Hamdy, Lars Holmberg, Dragan Ilic, Timothy J. Key, Carlo La Vecchia, Hans Lilja, Michael Marberger, Frank L. Meyskens, Lori M. Minasian, Chris Parker, Howard L. Parnes, Sven PernerHarry Rittenhouse, Jack Schalken, Hans Peter Schmid, Bernd J. Schmitz-Dräger, Fritz H. Schröder, Arnulf Stenzl, Bertrand Tombal, Timothy J. Wilt, Alicja Wolk

Research output: Contribution to journalReview article

203 Scopus citations

Abstract

Prostate cancer is a common malignancy in men and the worldwide burden of this disease is rising. Lifestyle modifications such as smoking cessation, exercise, and weight control offer opportunities to reduce the risk of developing prostate cancer. Early detection of prostate cancer by prostate-specific antigen (PSA) screening is controversial, but changes in the PSA threshold, frequency of screening, and the use of other biomarkers have the potential to minimise the overdiagnosis associated with PSA screening. Several new biomarkers for individuals with raised PSA concentrations or those diagnosed with prostate cancer are likely to identify individuals who can be spared aggressive treatment. Several pharmacological agents such as 5α-reductase inhibitors and aspirin could prevent development of prostate cancer. In this Review, we discuss the present evidence and research questions regarding prevention, early detection of prostate cancer, and management of men either at high risk of prostate cancer or diagnosed with low-grade prostate cancer.

Original languageEnglish (US)
Pages (from-to)e484-e492
JournalThe Lancet Oncology
Volume15
Issue number11
DOIs
StatePublished - Oct 1 2014

Fingerprint Dive into the research topics of 'Prevention and early detection of prostate cancer'. Together they form a unique fingerprint.

  • Cite this

    Cuzick, J., Thorat, M. A., Andriole, G., Brawley, O. W., Brown, P. H., Culig, Z., Eeles, R. A., Ford, L. G., Hamdy, F. C., Holmberg, L., Ilic, D., Key, T. J., Vecchia, C. L., Lilja, H., Marberger, M., Meyskens, F. L., Minasian, L. M., Parker, C., Parnes, H. L., ... Wolk, A. (2014). Prevention and early detection of prostate cancer. The Lancet Oncology, 15(11), e484-e492. https://doi.org/10.1016/S1470-2045(14)70211-6