Preventing unfolded protein response-induced ion channel dysregulation to treat arrhythmias

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Cardiomyopathies are associated with arrhythmias and cardiac ion channel downregulation. This downregulation is arrhythmogenic. Paradoxically, antiarrhythmic therapies are based on ion channel-blocking drugs that further downregulate these channels and exhibit proarrhythmic risk. Recent studies have shown that inhibition of the protein kinase RNA-like ER kinase (PERK) arm of the unfolded protein response (UPR) prevents select cardiac ion channel downregulation and plays a protective role against arrhythmias. Prevention of ion channel downregulation represents as a novel therapeutic strategy to treat arrhythmias in myocardial infarction and heart failure.

Original languageEnglish (US)
Pages (from-to)443-451
Number of pages9
JournalTrends in Molecular Medicine
Issue number6
StatePublished - Jun 2022

Bibliographical note

Funding Information:
This work is supported by R01 HL104025 (SCD) and Rhode Island Foundation grant 20154145 (M.L.).

Publisher Copyright:
© 2022 Elsevier Ltd


  • cardiac ion channel
  • heart failure
  • mRNA degradation
  • myocardial infarction
  • therapy

PubMed: MeSH publication types

  • Journal Article
  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't


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