Preventing T cell rejection of pig xenografts

Laura Higginbotham, Mandy L. Ford, Kenneth A. Newell, Andrew B. Adams

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

Xenotransplantation is a potential solution to the limited supply of donor organs. While early barriers to xenograft acceptance, such as hyperacute rejection, are now largely avoided through genetic engineering, the next frontier in successful xenograft survival will require prevention of T cell-mediated rejection. Most successful immunosuppressive regimens in xenotransplantation utilize T cell depletion with antibody therapy. Additionally, the use of T cell costimulatory blockade - specifically blockade of the CD40-CD154 pathway - shows promise with several reports of long-term xenograft survival. Additional therapies, such as transgenic expression of T cell coinhibitory molecules or transfer of immunomodulatory cells to promote tolerance, may be necessary to achieve reliable long-term xenograft acceptance. Further studies in pre-clinical models are essential in order to optimize these regimens prior to trials in patients.

Original languageEnglish (US)
Pages (from-to)285-290
Number of pages6
JournalInternational Journal of Surgery
Volume23
DOIs
StatePublished - Nov 1 2015
Externally publishedYes

Bibliographical note

Funding Information:
Work on xenotransplantation by the Emory Transplant Center at Emory University is supported by institutional funding . L.H. is supported by an NIH Ruth L. Kirschstein NRSA Institutional Research Training Grant ( T32 ).

Publisher Copyright:
© 2015.

Keywords

  • Cellular rejection
  • Nonhuman primate
  • Pig xenografts
  • Renal transplant
  • T cell-mediated rejection
  • Xenotransplantation

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