Preventing Congenital Cytomegalovirus Infection: Protection to a 'T'

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Abstract

A lack of knowledge about the correlates of maternal immunity required for protection of the placenta and fetus against congenital cytomegalovirus (CMV) transmission has complicated vaccine development. New work from Bialas and colleagues demonstrates a critical role for maternal CD4+ T cells in controlling viremia and preventing CMV-associated fetal disease.

Original languageEnglish (US)
Pages (from-to)170-172
Number of pages3
JournalTrends in Microbiology
Volume24
Issue number3
DOIs
StatePublished - Mar 1 2016

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Keywords

  • Animal models
  • Congenital cytomegalovirus infection
  • Cytomegalovirus immunity
  • Cytomegalovirus vaccine
  • Pentameric complex
  • Placenta

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