Preventing Congenital Cytomegalovirus Infection: Protection to a 'T'

Mark R. Schleiss

doi:10.1016/j.tim.2016.01.007

Preventing Congenital Cytomegalovirus Infection: Protection to a 'T'

Mark R. Schleiss

Research output: Contribution to journal › Short survey › peer-review

8 Scopus citations

Abstract

A lack of knowledge about the correlates of maternal immunity required for protection of the placenta and fetus against congenital cytomegalovirus (CMV) transmission has complicated vaccine development. New work from Bialas and colleagues demonstrates a critical role for maternal CD4⁺ T cells in controlling viremia and preventing CMV-associated fetal disease.

Original language	English (US)
Pages (from-to)	170-172
Number of pages	3
Journal	Trends in Microbiology
Volume	24
Issue number	3
DOIs	https://doi.org/10.1016/j.tim.2016.01.007
State	Published - Mar 1 2016

Bibliographical note

Funding Information:
Support from National Institutes of Health grants HD082273, HD044864, HD079918, and AI114013 is acknowledged.

Publisher Copyright:
© 2016.

Keywords

Animal models
Congenital cytomegalovirus infection
Cytomegalovirus immunity
Cytomegalovirus vaccine
Pentameric complex
Placenta

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10.1016/j.tim.2016.01.007

http://europepmc.org/articles/pmc4836615

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title = "Preventing Congenital Cytomegalovirus Infection: Protection to a 'T'",

abstract = "A lack of knowledge about the correlates of maternal immunity required for protection of the placenta and fetus against congenital cytomegalovirus (CMV) transmission has complicated vaccine development. New work from Bialas and colleagues demonstrates a critical role for maternal CD4+ T cells in controlling viremia and preventing CMV-associated fetal disease.",

keywords = "Animal models, Congenital cytomegalovirus infection, Cytomegalovirus immunity, Cytomegalovirus vaccine, Pentameric complex, Placenta",

author = "Schleiss, {Mark R.}",

note = "Funding Information: Support from National Institutes of Health grants HD082273, HD044864, HD079918, and AI114013 is acknowledged. Publisher Copyright: {\textcopyright} 2016.",

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T1 - Preventing Congenital Cytomegalovirus Infection

T2 - Protection to a 'T'

AU - Schleiss, Mark R.

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Y1 - 2016/3/1

N2 - A lack of knowledge about the correlates of maternal immunity required for protection of the placenta and fetus against congenital cytomegalovirus (CMV) transmission has complicated vaccine development. New work from Bialas and colleagues demonstrates a critical role for maternal CD4+ T cells in controlling viremia and preventing CMV-associated fetal disease.

AB - A lack of knowledge about the correlates of maternal immunity required for protection of the placenta and fetus against congenital cytomegalovirus (CMV) transmission has complicated vaccine development. New work from Bialas and colleagues demonstrates a critical role for maternal CD4+ T cells in controlling viremia and preventing CMV-associated fetal disease.

KW - Animal models

KW - Congenital cytomegalovirus infection

KW - Cytomegalovirus immunity

KW - Cytomegalovirus vaccine

KW - Pentameric complex

KW - Placenta

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JF - Trends in Microbiology

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ER -

Preventing Congenital Cytomegalovirus Infection: Protection to a 'T'

Abstract

Bibliographical note

Keywords

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