TY - JOUR
T1 - Prevalencia y caracterización de las neoplasias malignas en personas viviendo con VIH en Colombia
AU - Grupo colombiano de VIH (VIHCOL)
AU - Arévalo-Mora, Leonardo
AU - Martínez-Buitrago, Ernesto
AU - Posada, María Paulina
AU - Valderrama-Beltrán, Sandra Liliana
AU - Segura, Sandra
AU - García, Martha Milena
AU - Sussmann, Otto
AU - Hernández, Beatriz
AU - Andrade, Javier
AU - Lenis, William
AU - Mantilla, Mónica
AU - González, Claudia
AU - Franco, Julieta
AU - Galindo, Ximena
AU - Mueses, Héctor Fabio
AU - Alzate-ángel, Juan Carlos
AU - Fonseca, Norberto
AU - Duque, Olga García
AU - Ramos, Olga
AU - Montero, Leonardo
AU - Cuartas, Ángela
AU - Pardo, José Antonio
AU - Escandón, Kevin
N1 - Publisher Copyright:
© 2023, Sociedad Chilena de Infectologia. All rights reserved.
PY - 2023
Y1 - 2023
N2 - Background: In the acquired immunodeficiency syndrome, neoplasms have played a preponderant role, and with the advent of antiretroviral treatment (ART), HIV has become a chronic disease, with malignant tumors being an important cause of morbidity and mortality. Aim: To describe the demographic, clinical, and laboratory characteristics of people living with HIV (PLHIV) who have been diagnosed with cancer in Colombia and to compare the groups of AIDS-defining (ADC) and non-AIDS-defining neoplasms (NADC). Methods: Retrospective, multicenter study that included people living with HIV/AIDS (PLHIV) diagnosed with malignancies treated at 23 HIV care centers located in 11 Colombian cities from 1986 to 2018. Data related to HIV infection and cancer diagnosis were collected and analyzed. Results: Among 23,189 patients, 650 malignancy cases were identified (prevalence of 2.8% [95% CI 2.6-2.9]). AIDS-defining neoplasm remains the most prevalent type of cancer (71.1%), The most frequent individual malignancies were Kaposi sarcoma (n: 330; 50.8%), non-Hodgkin lymphoma (n: 110; 16.9%), skin cancer (n: 48; 7.4%), and Hodgkin lymphoma (n: 25; 3.8%). Compared people with NADC, with ADC were more likely to be MSM and have a CDC HIV stage 3, CD4 T cell count < 200/µL, and HIV viral load ≥ 50 copies/mL at the time of malignancy diagnosis. PLHIV and with NADC were significantly older and were more likely to be smokers. Conclusions: These findings are relevant considering the increasing burden of cancer in the aging PLHIV and the changing causes of morbidity and mortality. Late presentation to HIV care and delayed ART initiation are likely factors contributing to the slower shift toward NADCs compared with high-income regions where access to ART is better. Knowledge of the current epidemiological trends and profile of cancer in PLWHA is critical to improve cancer prevention and treatment efforts in the context of comprehensive HIV care.
AB - Background: In the acquired immunodeficiency syndrome, neoplasms have played a preponderant role, and with the advent of antiretroviral treatment (ART), HIV has become a chronic disease, with malignant tumors being an important cause of morbidity and mortality. Aim: To describe the demographic, clinical, and laboratory characteristics of people living with HIV (PLHIV) who have been diagnosed with cancer in Colombia and to compare the groups of AIDS-defining (ADC) and non-AIDS-defining neoplasms (NADC). Methods: Retrospective, multicenter study that included people living with HIV/AIDS (PLHIV) diagnosed with malignancies treated at 23 HIV care centers located in 11 Colombian cities from 1986 to 2018. Data related to HIV infection and cancer diagnosis were collected and analyzed. Results: Among 23,189 patients, 650 malignancy cases were identified (prevalence of 2.8% [95% CI 2.6-2.9]). AIDS-defining neoplasm remains the most prevalent type of cancer (71.1%), The most frequent individual malignancies were Kaposi sarcoma (n: 330; 50.8%), non-Hodgkin lymphoma (n: 110; 16.9%), skin cancer (n: 48; 7.4%), and Hodgkin lymphoma (n: 25; 3.8%). Compared people with NADC, with ADC were more likely to be MSM and have a CDC HIV stage 3, CD4 T cell count < 200/µL, and HIV viral load ≥ 50 copies/mL at the time of malignancy diagnosis. PLHIV and with NADC were significantly older and were more likely to be smokers. Conclusions: These findings are relevant considering the increasing burden of cancer in the aging PLHIV and the changing causes of morbidity and mortality. Late presentation to HIV care and delayed ART initiation are likely factors contributing to the slower shift toward NADCs compared with high-income regions where access to ART is better. Knowledge of the current epidemiological trends and profile of cancer in PLWHA is critical to improve cancer prevention and treatment efforts in the context of comprehensive HIV care.
KW - AIDS
KW - Colombia
KW - HIV
KW - neoplasm
KW - prevalence
UR - http://www.scopus.com/inward/record.url?scp=85178961596&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85178961596&partnerID=8YFLogxK
U2 - 10.4067/s0716-10182023000500514
DO - 10.4067/s0716-10182023000500514
M3 - Article
AN - SCOPUS:85178961596
SN - 0716-1018
VL - 40
SP - 514
EP - 528
JO - Revista Chilena de Infectologia
JF - Revista Chilena de Infectologia
IS - 5
ER -