TY - JOUR
T1 - Prevalence of HIV-1 and oral lesions in pregnant women in rural Malawi
AU - Muzyka, B. C.
AU - Kamwendo, L.
AU - Mbweza, E.
AU - Lopez, N. B.
AU - Glick, M.
AU - Matheson, P. B.
AU - Kershbaumer, R.
AU - Nyrienda, T.
AU - Malamud, D.
AU - Constantine, N. T.
AU - Thompson, J.
AU - Nyasulu, Y.
AU - Saville, R.
AU - Berthold, P.
N1 - Funding Information:
Supported by the Provost International Research Fund, University of Pennsylvania, Philadelphia, Pa; Epitope Inc, Beaverton, Ore; Organon Technica, Inc, Raleigh, NC; British Airways, Philadelphia office, Pa; Henry Schein, Florham Park, NJ; CareLift, Philadelphia, Pa; and Prism Enterprises, Inc, San Antonio, Tex.
PY - 2001/7
Y1 - 2001/7
N2 - Objective. Whether oral lesions were associated with human immunodeficiency virus-type 1 (HIV-1) status in a cohort of pregnant Malawian women was studied. Study design. Six hundred thirty-eight women participated in a randomized prospective study at 3 prenatal clinics in a rural area of southern Malawi. Oral examinations, followed by collection of oral fluid specimens with an HIV-1 oral specimen collection device, were performed. The specimens were tested for antibodies against HIV-1. Results. Sixty-one oral lesions were found in 60 participants. While traditional HIV-1 associated lesions were rare, benign migratory glossitis was unexpectedly common (6%). Oral hairy leukoplakia was significantly more common among women who were HIV-1 positive than among women who were HIV-1 negative. An HIV-1 prevalence rate of 21.8% was estimated among the women, with the highest rate of HIV-1 infection (34.1%) among women aged 25 to 29 years. Conclusion. Stratifying lesions showed a small number of oral hairy leukoplakia to be markers for HIV-1. A high seroprevalence was found in this rural cohort, but there were unexpectedly few oral lesions. The relatively few oral lesions diagnosed may indicate a recent infection with HIV.
AB - Objective. Whether oral lesions were associated with human immunodeficiency virus-type 1 (HIV-1) status in a cohort of pregnant Malawian women was studied. Study design. Six hundred thirty-eight women participated in a randomized prospective study at 3 prenatal clinics in a rural area of southern Malawi. Oral examinations, followed by collection of oral fluid specimens with an HIV-1 oral specimen collection device, were performed. The specimens were tested for antibodies against HIV-1. Results. Sixty-one oral lesions were found in 60 participants. While traditional HIV-1 associated lesions were rare, benign migratory glossitis was unexpectedly common (6%). Oral hairy leukoplakia was significantly more common among women who were HIV-1 positive than among women who were HIV-1 negative. An HIV-1 prevalence rate of 21.8% was estimated among the women, with the highest rate of HIV-1 infection (34.1%) among women aged 25 to 29 years. Conclusion. Stratifying lesions showed a small number of oral hairy leukoplakia to be markers for HIV-1. A high seroprevalence was found in this rural cohort, but there were unexpectedly few oral lesions. The relatively few oral lesions diagnosed may indicate a recent infection with HIV.
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U2 - 10.1067/moe.2001.112542
DO - 10.1067/moe.2001.112542
M3 - Article
C2 - 11458246
AN - SCOPUS:0035403127
SN - 1079-2104
VL - 92
SP - 56
EP - 61
JO - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
JF - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
IS - 1
ER -
