Prevalence of conception and pregnancy outcomes after hematopoietic cell transplantation: Report from the bone marrow transplant survivor study

A. Carter, L. L. Robison, L. Francisco, D. Smith, M. Grant, K. S. Baker, J. G. Gurney, P. B. McGlave, D. J. Weisdorf, S. J. Forman, S. Bhatia

Research output: Contribution to journalArticlepeer-review

101 Scopus citations

Abstract

We conducted a retrospective study to describe the magnitude of compromise in reproductive function and investigate pregnancy outcomes in 619 women and partners of men treated with autologous (n=241) or allogeneic (n=378) hematopoietic cell transplantation (HCT) between 21 and 45 years of age, and surviving 2 or more years. Median age at HCT was 33.3 years and median time since HCT 7.7 years. Mailed questionnaires captured pregnancies and their outcomes (live birth, stillbirth, miscarriage). Thirty-four patients reported 54 pregnancies after HCT (26 males, 40 pregnancies; eight females, 14 pregnancies), of which 46 resulted in live births. Factors associated with reporting no conception included older age at HCT (≥30 years: odds ratio (OR)=4.8), female sex (OR=3.0), and total body irradiation (OR=3.3). Prevalence of conception and pregnancy outcomes in HCT survivors were compared to those of 301 nearest-age siblings. Although the risk for not reporting a conception was significantly increased among HCT survivors (OR=36), survivors were not significantly more likely than siblings to report miscarriage or stillbirth (OR=0.7). Although prevalence of conception is diminished after HCT, if pregnancy does occur, outcome is likely to be favorable. Patients should be counseled prior to transplant regarding strategies to preserve fertility.

Original languageEnglish (US)
Pages (from-to)1023-1029
Number of pages7
JournalBone marrow transplantation
Volume37
Issue number11
DOIs
StatePublished - Jun 2006

Bibliographical note

Funding Information:
This work was supported in part by R01 CA078938 from the National Cancer Institute, and The Lymphoma-Leukemia Society of America Clinical Scholar Award 2191-02. This study was presented at the American Society of Hematology, San Diego, CA, 2004.

Keywords

  • Conception
  • Hematopoietic cell transplantation
  • Late effects
  • Pregnancy outcomes

Fingerprint Dive into the research topics of 'Prevalence of conception and pregnancy outcomes after hematopoietic cell transplantation: Report from the bone marrow transplant survivor study'. Together they form a unique fingerprint.

Cite this