Prevalence and severity of dysphonia in patients with cystic fibrosis: A pilot study

John Willis, Deirdre D. Michael, Holly Boyer, Stephanie Misono

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Objective. To assess the prevalence and severity of dysphonia in patients with cystic fibrosis sinusitis. We hypothesized that patients with CF sinusitis, compared with 2 control groups, would have higher self-reported prevalence of dysphonia and greater severity of dysphonia, according to patient-reported outcome measures as well as auditoryperceptual evaluation by expert listeners. Study Design. Cross-sectional comparative pilot study. Setting. Academic tertiary care clinic. Study Participants and Methods. Analysis included 37 study participants: 17 patients with CF sinusitis, 10 healthy individuals, and 10 patients with non-CF sinusitis. All participants completed the 10-item Voice Handicap Index (VHI-10) questionnaire and provided voice samples. On all samples, 6 blinded speech-language pathologists independently performed auditory-perceptual evaluation, using Consensus Auditory-Perceptual Evaluation of Voice. To assess severity of sinonasal symptoms, we used the 20-item Sinonasal Outcome Test (SNOT-20). Standard parametric and nonparametric statistical analysis was performed. Results. The differences between the 3 groups in prevalence of abnormal VHI-10 scores were not statistically significant. SNOT-20 scores were similar in the 2 sinusitis patient groups. VHI-10 scores were highest in patients with CF sinusitis, intermediate in patients with non-CF sinusitis, and lowest in healthy individuals (P = .005). Auditory-perceptual evaluation demonstrated greater overall severity of dysphonia in patients with CF sinusitis compared with the 2 control groups (P = .0005). Conclusions. Cystic fibrosis sinusitis appeared to be associated with worse vocal function as measured by patient selfreport as well as auditory-perceptual evaluation of voice compared with patients with non-CF sinusitis and healthy controls. Further investigation in this area is warranted.

Original languageEnglish (US)
Pages (from-to)88-93
Number of pages6
JournalOtolaryngology - Head and Neck Surgery (United States)
Issue number1
StatePublished - Jul 3 2015

Bibliographical note

Funding Information:
Funding source: Lions Research Foundation Grant and NIH UL1TR000114.

Publisher Copyright:
© American Academy of Otolaryngology-Head and Neck Surgery Foundation 2015.


  • auditory-perceptual
  • chronic sinusitis
  • cystic fibrosis
  • dysphonia
  • sinusitis
  • voice handicap


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