Prevalence and genetic relatedness of methicillin-susceptible Staphylococcus aureus isolates detected by the Xpert MRSA nasal assay

Sophie S. Arbefeville; Kunyan Zhang; Jennifer S. Kroeger; Wanita J. Howard; Daniel J. Diekema; Sandra S. Richter

doi:10.1128/JCM.00046-11

Prevalence and genetic relatedness of methicillin-susceptible Staphylococcus aureus isolates detected by the Xpert MRSA nasal assay

Sophie S. Arbefeville, Kunyan Zhang, Jennifer S. Kroeger, Wanita J. Howard, Daniel J. Diekema, Sandra S. Richter

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Methicillin-susceptible Staphylococcus aureus (MSSA) isolates lacking mecA yet testing positive on the Xpert MRSA assay were recovered from culture for 7.7% of 248 Xpert-positive nasal samples. These "false-positive" Xpert results may be attributed to staphylococcal cassette chromosome (SCC) elements without the mecA gene. Pulsed-field gel electrophoresis (PFGE) analysis revealed a diverse population of MSSA strains.

Original language	English (US)
Pages (from-to)	2996-2999
Number of pages	4
Journal	Journal of clinical microbiology
Volume	49
Issue number	8
DOIs	https://doi.org/10.1128/JCM.00046-11
State	Published - Aug 2011

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abstract = "Methicillin-susceptible Staphylococcus aureus (MSSA) isolates lacking mecA yet testing positive on the Xpert MRSA assay were recovered from culture for 7.7% of 248 Xpert-positive nasal samples. These {"}false-positive{"} Xpert results may be attributed to staphylococcal cassette chromosome (SCC) elements without the mecA gene. Pulsed-field gel electrophoresis (PFGE) analysis revealed a diverse population of MSSA strains.",

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AU - Arbefeville, Sophie S.

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AU - Kroeger, Jennifer S.

AU - Howard, Wanita J.

AU - Diekema, Daniel J.

AU - Richter, Sandra S.

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AB - Methicillin-susceptible Staphylococcus aureus (MSSA) isolates lacking mecA yet testing positive on the Xpert MRSA assay were recovered from culture for 7.7% of 248 Xpert-positive nasal samples. These "false-positive" Xpert results may be attributed to staphylococcal cassette chromosome (SCC) elements without the mecA gene. Pulsed-field gel electrophoresis (PFGE) analysis revealed a diverse population of MSSA strains.

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Prevalence and genetic relatedness of methicillin-susceptible Staphylococcus aureus isolates detected by the Xpert MRSA nasal assay

Abstract

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