Pretransplant Gut Colonization with Intrinsically Vancomycin-Resistant Enterococci (E. gallinarum and E. casseliflavus) and Outcomes of Allogeneic Hematopoietic Cell Transplantation

Armin Rashidi; Maryam Ebadi; Robin R Shields-Cutler; Todd E De For; Gabriel A. Al-Ghalith; Patricia Ferrieri; Jo-Anne H Young; Gary M Dunny; Dan Knights; Daniel J Weisdorf

doi:10.1016/j.bbmt.2018.01.025

Pretransplant Gut Colonization with Intrinsically Vancomycin-Resistant Enterococci (E. gallinarum and E. casseliflavus) and Outcomes of Allogeneic Hematopoietic Cell Transplantation

Armin Rashidi, Maryam Ebadi, Robin R Shields-Cutler, Todd E De For, Gabriel A. Al-Ghalith, Patricia Ferrieri, Jo-Anne H Young, Gary M Dunny, Dan Knights, Daniel J Weisdorf

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Pretransplant gut colonization with intrinsically vancomycin-resistant enterococci (iVRE) (Enterococcus gallinarum and Enterococcus casseliflavus) is uncommon and with unknown clinical impact. In a matched-pairs analysis of patients with versus without iVRE colonization (n = 18 in each group), we demonstrated significantly higher 2-year overall survival (86% [95% confidence interval, 52% to 96%] versus 35% [95% confidence interval, 8% to 65]; P <.01) and lower nonrelapse mortality (P <.01) among colonized patients. Putative metabolomes differentiated iVRE from E. faecalis/faecium and may contribute to a healthier gut microbiome in iVRE-colonized patients.

Original language	English (US)
Pages (from-to)	1260-1263
Number of pages	4
Journal	Biology of Blood and Marrow Transplantation
Volume	24
Issue number	6
DOIs	https://doi.org/10.1016/j.bbmt.2018.01.025
State	Published - Jun 2018

Bibliographical note

Publisher Copyright:
© 2018 The American Society for Blood and Marrow Transplantation

Keywords

Allogeneic
Biosynthetic
Colonization
Enterococcus
Vancomycin

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10.1016/j.bbmt.2018.01.025

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Rashidi, A., Ebadi, M., Shields-Cutler, R. R., De For, T. E., Al-Ghalith, G. A., Ferrieri, P., Young, J.-A. H., Dunny, G. M., Knights, D., & Weisdorf, D. J. (2018). Pretransplant Gut Colonization with Intrinsically Vancomycin-Resistant Enterococci (E. gallinarum and E. casseliflavus) and Outcomes of Allogeneic Hematopoietic Cell Transplantation. Biology of Blood and Marrow Transplantation, 24(6), 1260-1263. https://doi.org/10.1016/j.bbmt.2018.01.025

Pretransplant Gut Colonization with Intrinsically Vancomycin-Resistant Enterococci (E. gallinarum and E. casseliflavus) and Outcomes of Allogeneic Hematopoietic Cell Transplantation. / Rashidi, Armin; Ebadi, Maryam; Shields-Cutler, Robin R et al.
In: Biology of Blood and Marrow Transplantation, Vol. 24, No. 6, 06.2018, p. 1260-1263.

Research output: Contribution to journal › Article › peer-review

Rashidi, A, Ebadi, M, Shields-Cutler, RR , De For, TE, Al-Ghalith, GA, Ferrieri, P , Young, J-AH, Dunny, GM, Knights, D & Weisdorf, DJ 2018, 'Pretransplant Gut Colonization with Intrinsically Vancomycin-Resistant Enterococci (E. gallinarum and E. casseliflavus) and Outcomes of Allogeneic Hematopoietic Cell Transplantation', Biology of Blood and Marrow Transplantation, vol. 24, no. 6, pp. 1260-1263. https://doi.org/10.1016/j.bbmt.2018.01.025

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abstract = "Pretransplant gut colonization with intrinsically vancomycin-resistant enterococci (iVRE) (Enterococcus gallinarum and Enterococcus casseliflavus) is uncommon and with unknown clinical impact. In a matched-pairs analysis of patients with versus without iVRE colonization (n = 18 in each group), we demonstrated significantly higher 2-year overall survival (86% [95% confidence interval, 52% to 96%] versus 35% [95% confidence interval, 8% to 65]; P <.01) and lower nonrelapse mortality (P <.01) among colonized patients. Putative metabolomes differentiated iVRE from E. faecalis/faecium and may contribute to a healthier gut microbiome in iVRE-colonized patients.",

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author = "Armin Rashidi and Maryam Ebadi and Shields-Cutler, {Robin R} and {De For}, {Todd E} and Al-Ghalith, {Gabriel A.} and Patricia Ferrieri and Young, {Jo-Anne H} and Dunny, {Gary M} and Dan Knights and Weisdorf, {Daniel J}",

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doi = "10.1016/j.bbmt.2018.01.025",

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AU - Ebadi, Maryam

AU - Shields-Cutler, Robin R

AU - De For, Todd E

AU - Al-Ghalith, Gabriel A.

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AU - Young, Jo-Anne H

AU - Dunny, Gary M

AU - Knights, Dan

AU - Weisdorf, Daniel J

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AB - Pretransplant gut colonization with intrinsically vancomycin-resistant enterococci (iVRE) (Enterococcus gallinarum and Enterococcus casseliflavus) is uncommon and with unknown clinical impact. In a matched-pairs analysis of patients with versus without iVRE colonization (n = 18 in each group), we demonstrated significantly higher 2-year overall survival (86% [95% confidence interval, 52% to 96%] versus 35% [95% confidence interval, 8% to 65]; P <.01) and lower nonrelapse mortality (P <.01) among colonized patients. Putative metabolomes differentiated iVRE from E. faecalis/faecium and may contribute to a healthier gut microbiome in iVRE-colonized patients.

KW - Allogeneic

KW - Biosynthetic

KW - Colonization

KW - Enterococcus

KW - Vancomycin

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Pretransplant Gut Colonization with Intrinsically Vancomycin-Resistant Enterococci (E. gallinarum and E. casseliflavus) and Outcomes of Allogeneic Hematopoietic Cell Transplantation

Abstract

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Keywords

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