Presumed primary immune-mediated thrombocytopenia in four cats

Domenico Bianco, P. Jane Armstrong, Robert J Washabau, VMD, PhD

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Feline primary immune-mediated thrombocytopenia (pIMT) is a rare hematological disorder. Platelet-bound antibody assays for cats have variable specificity and sensitivity and are not widely available. Diagnosis of pIMT is made on the basis of exclusion of other identifiable causes of thrombocytopenia and the response to immunosuppressive therapy. This report describes four cats with severe thrombocytopenia and no detectable underlying disease. One cat was euthanased because of pulmonary hemorrhage, while the other cats had frequent relapses, two of these cats developed diabetes mellitus due to long-term corticosteroid therapy. In these cats IMT had a chronic course and responded poorly to therapy with prednisolone. Alternative immunomodulatory drugs may be considered in the treatment of feline IMT.

Original languageEnglish (US)
Pages (from-to)495-500
Number of pages6
JournalJournal of Feline Medicine and Surgery
Volume10
Issue number5
DOIs
StatePublished - Oct 1 2008

Fingerprint

Idiopathic Thrombocytopenic Purpura
thrombocytopenia
Cats
cats
Felidae
Thrombocytopenia
therapeutics
Immunosuppressive Agents
Prednisolone
immunosuppressive agents
prednisolone
Diabetes Mellitus
relapse
Adrenal Cortex Hormones
adrenal cortex hormones
Therapeutics
Blood Platelets
diabetes mellitus
chronic diseases
Hemorrhage

Cite this

Presumed primary immune-mediated thrombocytopenia in four cats. / Bianco, Domenico; Armstrong, P. Jane; Washabau, VMD, PhD, Robert J.

In: Journal of Feline Medicine and Surgery, Vol. 10, No. 5, 01.10.2008, p. 495-500.

Research output: Contribution to journalArticle

@article{8bf9d6bcb4aa40dcb5899501b4d47df3,
title = "Presumed primary immune-mediated thrombocytopenia in four cats",
abstract = "Feline primary immune-mediated thrombocytopenia (pIMT) is a rare hematological disorder. Platelet-bound antibody assays for cats have variable specificity and sensitivity and are not widely available. Diagnosis of pIMT is made on the basis of exclusion of other identifiable causes of thrombocytopenia and the response to immunosuppressive therapy. This report describes four cats with severe thrombocytopenia and no detectable underlying disease. One cat was euthanased because of pulmonary hemorrhage, while the other cats had frequent relapses, two of these cats developed diabetes mellitus due to long-term corticosteroid therapy. In these cats IMT had a chronic course and responded poorly to therapy with prednisolone. Alternative immunomodulatory drugs may be considered in the treatment of feline IMT.",
author = "Domenico Bianco and Armstrong, {P. Jane} and {Washabau, VMD, PhD}, {Robert J}",
year = "2008",
month = "10",
day = "1",
doi = "10.1016/j.jfms.2008.01.003",
language = "English (US)",
volume = "10",
pages = "495--500",
journal = "Journal of Feline Medicine and Surgery",
issn = "1098-612X",
publisher = "W.B. Saunders Ltd",
number = "5",

}

TY - JOUR

T1 - Presumed primary immune-mediated thrombocytopenia in four cats

AU - Bianco, Domenico

AU - Armstrong, P. Jane

AU - Washabau, VMD, PhD, Robert J

PY - 2008/10/1

Y1 - 2008/10/1

N2 - Feline primary immune-mediated thrombocytopenia (pIMT) is a rare hematological disorder. Platelet-bound antibody assays for cats have variable specificity and sensitivity and are not widely available. Diagnosis of pIMT is made on the basis of exclusion of other identifiable causes of thrombocytopenia and the response to immunosuppressive therapy. This report describes four cats with severe thrombocytopenia and no detectable underlying disease. One cat was euthanased because of pulmonary hemorrhage, while the other cats had frequent relapses, two of these cats developed diabetes mellitus due to long-term corticosteroid therapy. In these cats IMT had a chronic course and responded poorly to therapy with prednisolone. Alternative immunomodulatory drugs may be considered in the treatment of feline IMT.

AB - Feline primary immune-mediated thrombocytopenia (pIMT) is a rare hematological disorder. Platelet-bound antibody assays for cats have variable specificity and sensitivity and are not widely available. Diagnosis of pIMT is made on the basis of exclusion of other identifiable causes of thrombocytopenia and the response to immunosuppressive therapy. This report describes four cats with severe thrombocytopenia and no detectable underlying disease. One cat was euthanased because of pulmonary hemorrhage, while the other cats had frequent relapses, two of these cats developed diabetes mellitus due to long-term corticosteroid therapy. In these cats IMT had a chronic course and responded poorly to therapy with prednisolone. Alternative immunomodulatory drugs may be considered in the treatment of feline IMT.

UR - http://www.scopus.com/inward/record.url?scp=51249090907&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=51249090907&partnerID=8YFLogxK

U2 - 10.1016/j.jfms.2008.01.003

DO - 10.1016/j.jfms.2008.01.003

M3 - Article

C2 - 18339567

AN - SCOPUS:51249090907

VL - 10

SP - 495

EP - 500

JO - Journal of Feline Medicine and Surgery

JF - Journal of Feline Medicine and Surgery

SN - 1098-612X

IS - 5

ER -