Present and future of surface-enhanced Raman scattering

Judith Langer, Dorleta Jimenez de Aberasturi, Javier Aizpurua, Ramon A. Alvarez-Puebla, Baptiste Auguié, Jeremy J. Baumberg, Guillermo C. Bazan, Steven E.J. Bell, Anja Boisen, Alexandre G. Brolo, Jaebum Choo, Dana Cialla-May, Volker Deckert, Laura Fabris, Karen Faulds, F. Javier García de Abajo, Royston Goodacre, Duncan Graham, Amanda J. Haes, Christy L. HaynesChristian Huck, Tamitake Itoh, Mikael Käll, Janina Kneipp, Nicholas A. Kotov, Hua Kuang, Eric C. Le Ru, Hiang Kwee Lee, Jian Feng Li, Xing Yi Ling, Stefan A. Maier, Thomas Mayerhöfer, Martin Moskovits, Kei Murakoshi, Jwa Min Nam, Shuming Nie, Yukihiro Ozaki, Isabel Pastoriza-Santos, Jorge Perez-Juste, Juergen Popp, Annemarie Pucci, Stephanie Reich, Bin Ren, George C. Schatz, Timur Shegai, Sebastian Schlücker, Li Lin Tay, K. George Thomas, Zhong Qun Tian, Richard P. van Duyne, Tuan Vo-Dinh, Yue Wang, Katherine A. Willets, Chuanlai Xu, Hongxing Xu, Yikai Xu, Yuko S. Yamamoto, Bing Zhao, Luis M. Liz-Marzán

Research output: Contribution to journalReview articlepeer-review

274 Scopus citations


The discovery of the enhancement of Raman scattering by molecules adsorbed on nanostructured metal surfaces is a landmark in the history of spectroscopic and analytical techniques. Significant experimental and theoretical effort has been directed toward understanding the surface-enhanced Raman scattering (SERS) effect and demonstrating its potential in various types of ultrasensitive sensing applications in a wide variety of fields. In the 45 years since its discovery, SERS has blossomed into a rich area of research and technology, but additional efforts are still needed before it can be routinely used analytically and in commercial products. In this Review, prominent authors from around the world joined together to summarize the state of the art in understanding and using SERS and to predict what can be expected in the near future in terms of research, applications, and technological development. This Review is dedicated to SERS pioneer and our coauthor, the late Prof. Richard Van Duyne, whom we lost during the preparation of this article.

Original languageEnglish (US)
Pages (from-to)28-117
Number of pages90
JournalACS nano
Issue number1
StatePublished - Jan 28 2020

Bibliographical note

Funding Information:
We are sad to report that Richard P. Van Duyne passed away July 28, 2019. Rick was a key figure in the original discovery of SERS in the 1970s, as described in the text. Subsequently he was a giant in the development of the SERS technique, including important contributions to our understanding of single-molecule SERS, to the development of SERS substrates, to the discovery of enhanced nonlinear Raman-based methods, to the development of TERS and electrochemical SERS and TERS, and to the applications of SERS and related methods in a wide variety of directions related to sensing and surface chemistry. Rick also played a crucial role in mentoring students and postdocs, especially female scientists, who are now leaders in the SERS field. Funding is acknowledged from the European Research Council (ERC Advanced Grant No. 787510-4DBIOSERS to L.M.L.-M., ERC Advanced Grant No. 789104-eNANO to F.J.G.A., ERC Starting Grant No. 259432-MULTIBIOPHOT to J.K., ERC Consolidator Grant No. 772108-DarkSERS); the Department of Education of the Basque Government (Grant No. IT1164-19 to J.A.); the Spanish MINECO (CTQ2017-88648-R to R.A.-P., MAT2016-77809-R to I.P.-S. and J.P.-J.); the EPSRC (EP/P034063/1 to S.B., EP/L027151/1 to J.B., EP/L014165/1 to D.G. and K.F.); IDUN-Danish National Research Foundation (DNRF122) and Villum Fonden (Grant No. 9301) to A.B.; the National Research Foundation of Korea (Grant No. 2019R1A2C3004375 to J.B.); the German Science Foundation, DFG (SFB 1278 Polytarget (Project B4) to V.D., Grant No. SCHL 594/13-1 to S.S., Germany’s Excellence Strategy (EXC 2089/1-390776260) to S.M.); the Federal Ministry of Education and Research, Germany (BMBF) (Grant InfectoGnostics 13GW0096F to D.C.-M. and J.P.); DARPA-16-35-INTERCEPT-FP-018 to L.F.; the UK BBSRC (Grant No. BB/L014823/1 to R.G.); the Department of Science and Technology (DST Nanomission Project SR/NM/NS-23/2016 to K.G.T.); the U.S. National Science Foundation (Grant No. CHE-1707859 to A.J.H., Center for Sustainable Nanotechnology CHE-1503408 (Centers for Chemical Innovation Program) to C.L.H., Center for Chemical Innovation Chemistry at the Space-Time Limit (CaSTL) CHE-1414466 to G.C.S. and R.P.V.D., Grant No. CHE-1807269 to K.A.W.); the Knut and Alice Wallenberg Foundation to M.K.; the Office of Naval Research (Grant No. N00014-18-1-2876 to N.A.K.); Royal Society of New Zealand Te Apa̅rangi to E.L.R. and B.A.; Singapore Ministry of Education, Tier 1 (RG11/18) to X.Y.L.; the Photoexcitonix Project in Hokkaido Univ., Japan, to K.M.; BioNano Health-Guard Research Center funded by the Ministry of Science and ICT (MSIT) of Korea as Global Frontier Project (Grant No. H-GUARD_2013M3A6B2078947) to J.-M.N.; NSFC of P. R. China (Grant No. 21705015 to Y.O., Grant No. 21633005 to B.R.); National Key R&D Program (2017YFA0206902) to C.X. This work was coordinated under the Maria de Maeztu Units of Excellence Program from the Spanish State Research Agency—Grant No. MDM-2017-0720.


  • Biosensing
  • Catalysis
  • Charge transfer
  • Chemosensors
  • Hot electrons
  • Nanomedicine
  • SERS tags
  • Surface-enhanced Raman scattering
  • TERS

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

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